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Optics Express

Optics Express

  • Editor: J. H. Eberly
  • Vol. 5, Iss. 10 — Nov. 8, 1999
  • pp: 230–242

Differential diffuse optical tomography

Vasilis Ntziachristos, Britton Chance, and A.G. Yodh  »View Author Affiliations


Optics Express, Vol. 5, Issue 10, pp. 230-242 (1999)
http://dx.doi.org/10.1364/OE.5.000230


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Abstract

We formulate a perturbative solution for the heterogeneous diffusion equation which demonstrates how to use differential changes in diffuse light transmission to construct images of tissue absorption changes following contrast agent administration. The analysis exposes approximations leading to an intuitive and simplified inverse algorithm, shows explicitly why transmission geometries are less susceptible to error than the remission geometries, and why differential measurements are less susceptible to surface artifacts. These ideas about differential diffuse optical tomography are not only applicable to tumor detection and characterization using contrast agents, but also to functional activation studies with or without contrast agents and multi-wavelength measurements.

© Optical Society of America

OCIS Codes
(110.6960) Imaging systems : Tomography
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5270) Medical optics and biotechnology : Photon density waves
(170.5280) Medical optics and biotechnology : Photon migration
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Research Papers

History
Original Manuscript: September 8, 1999
Published: November 8, 1999

Citation
Vasilis Ntziachristos, Britton Chance, and Arjun Yodh, "Differential diffuse optical tomography," Opt. Express 5, 230-242 (1999)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-5-10-230


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