OSA's Digital Library

Optics Express

Optics Express

  • Editor: J. H. Eberly
  • Vol. 6, Iss. 13 — Jun. 19, 2000
  • pp: 243–250

Scanning laser reflectometry of retinal and subretinal tissues

A.E. Elsner, L. Moraes, E. Beausencourt, A. Remky, S.A. Burns, J.J. Weiter, J. P. Walker, G. L. Wing, P. A. Raskauskas, and L. M. Kelley  »View Author Affiliations

Optics Express, Vol. 6, Issue 13, pp. 243-250 (2000)

View Full Text Article

Enhanced HTML    Acrobat PDF (1228 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



Measurements of the human ocular fundus that make use of the light returning through the pupil are called reflectometry. Early reflectometry studies were limited by poor light return from the retina and strong reflections from the anterior surface of the eye. Artifacts produced misleading results in diseases like age-related macular degeneration. Novel laser sources, scanning, confocal optics, and digital imaging provide improved sampling of the signal from the tissues of interest: photoreceptors and retinal pigment epithelial cells. A wider range of wavelengths is now compared, including the near infrared. Reflectometry now provides functional mapping, even in severe pathology.

© Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4470) Medical optics and biotechnology : Ophthalmology
(330.4300) Vision, color, and visual optics : Vision system - noninvasive assessment

ToC Category:
Research Papers

Original Manuscript: April 27, 2000
Published: June 19, 2000

Ann Elsner, L. Moraes, E. Beausencourt, Andreas Remky, J. Weiter, J. Walker, G. Wing, Stephen Burns, P. Raskauskas, and L. Kelley, "Scanning laser reflectometry of retinal and subretinal tissues," Opt. Express 6, 243-250 (2000)

Sort:  Journal  |  Reset  


  1. F. C. Delori and K. P. Pflibsen, "Spectral reflectance of the human ocular fundus," Appl. Opt. 28, 1061-1077 (1989). [CrossRef] [PubMed]
  2. A. E. Elsner, S. A. Burns, J. J. Weiter and F. C. Delori, "Infrared imaging of subretinal structures in the human ocular fundus," Vision Res. 36, 191-205 (1996). [CrossRef] [PubMed]
  3. S. A. Burns, S. Wu, F. C. Delori and A. E. Elsner, "Direct Measurement of human cone photoreceptor alignment," J. Opt. Soc. Am. A 12, 2329-2338 (1995). [CrossRef]
  4. A. E. Elsner, S. A. Burns, G. W. Hughes and R. H. Webb, "Reflectometry with a Scanning Laser Ophthalmoscope," Appl. Opt. 31, 3697-3710 (1992). [CrossRef] [PubMed]
  5. S. Marcos, R.-P. Tornow, A. E. Elsner and R. Navarro, "Foveal cone spacing and cone photopigment density difference: objective measurements in the same subjects." Vision Res. 37, 1909-1915 (1997). [CrossRef] [PubMed]
  6. A. E. Elsner, S. A. Burns, E. Beausencourt and J. J. Weiter, "Foveal cone photopigment distribution: small alterations associated with macular pigment distribution," Invest. Ophthalmol. Vis. Sci. 39, 2394-2404 (1998). [PubMed]
  7. A. E. Elsner, S. A. Burns, F. C. Delori and R. H. Webb, "Quantitative Reflectometry with the SLO," in Laser Scanning Ophthalmoscopy and Tomography, J. E. Nasemann and R.O.W. Burk eds. (Quintessenz-Verlag, Munich, 1990), pp. 109-121.
  8. A. E, Elsner, S. A. Burns, M. R. Kreitz and J. J. Weiter, "New views of the retina/RPE complex: quantifying sub-retinal pathology," in Noninvasive Assessment of the Visual System, Vol, 1 of OSA Proceedings Series (Optical Society of America, Washington, D.C., 1991), pp. 150-153.
  9. A. E. Elsner, D.-U. Bartsch, J. J. Weiter and M. E. Hartnett, "New devices in retinal imaging and functional evaluation," in Practical Atlas of Retinal Disease and Therapy, W. Freeman ed. (Lippincott-Raven, New York, 1998) 2nd edition, pp. 19-55.
  10. L. M. Kelley, J. P. Walker, G. L. Wing, P. A. Raskauskas and A. E. Elsener, "Scanning laser ophthalmoscope imaging of age related macular degeneration and neoplasms," J. Ophthalmic Photography 3, 89-94 (1997).
  11. M E. Hartnett and A. E. Elsner, "Characteristics of exudative age-related macular degeneration determined in vivo with confocal direct and indirect infrared imaging," Ophthalmol. 103, 58-71 (1996).
  12. L. V. Johnson, S. Ozak, M. I. Staples, P. A., Erickson and D. H. Anderson, "Potential role for immune complex pathogenesis in drusen formation," Exp. Eye Res. 70, 441-449 (2000). [CrossRef] [PubMed]
  13. The longitudinal study and image of the first patient re-tested are at http://color.eri.harvard.edu/annhom.htm
  14. A. E. Elsner, L. Moraes, C. W. Kunze and M. E. Hartnett, "Foveal cone photopigment distribution in age-related macular degeneration: association with fundus features," in Vision Science and Its Applications, Vol. 1 of OSA Proceedings Series (Optical Society of America, Washington, D.C., 1998) pp.14-17.
  15. A. E. Elsner, A. Remky, E. Beausencourt and S. A. Burns, "A statistical method to quantify drusen in SLO images," in Vision Science and Its Applications, Vol. 1 of OSA Proceedings Series (Optical Society of America, Washington, D.C., 1996), pp. 268-271.
  16. R.-P. Tornow and R. Stilling, "Scanning laser densitometry and color perimetry demonstrate reduced photopigment density and sensitivity in two patients with retinal degeneration" Vision Res. 39, 3630-3641 (1999). [CrossRef]
  17. M. A. Sandberg, B. S. Pawlyk E. L. Berson, "Acuity recovery and cone pigment regeneration after a bleach in patients with retinitis pigmentosa and rhodopsin mutations," Invest. Ophthalmol. Vis. Sci. 40, 2457-2461 (1999). [PubMed]
  18. S. A. Burns, S. Wu, J. He, J and A. E. Elsner, "Variations in photoreceptor directionality across the central retina," J. Opt. Society Amer A 14, 2033-2040 (1997). [CrossRef]
  19. P. J. DeLint, T. T. Berendschot and D. A. van Norren, "A comparison of the optical Stiles-Crawford effect and retinal densitometry in a clinical setting," Invest. Ophthalmol. Vis. Sci. 39, 1519-1523 (1998). [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited