Imaging of in vitro and in vivo bones and joints with continuous-wave diffuse optical tomography
Optics Express, Vol. 8, Issue 7, pp. 447-451 (2001)
http://dx.doi.org/10.1364/OE.8.000447
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Abstract
We present what is believed to be the first absorption and scattering images of in vitro and in vivo bones and joints from continuous-wave tomographic measurements. Human finger and chicken bones embedded in cylindrical scattering media were imaged at multiple transverse planes with Clemson multi-channel diffuse optical imager. Both absorption and scattering images were obtained using our nonlinear, finite element based reconstruction algorithm. This study shows that diffuse optical tomography (DOT) has the potential to be used for detection and monitoring of bone and joint diseases such as osteoporosis and arthritis.
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OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6960) Medical optics and biotechnology : Tomography
ToC Category:
Research Papers
History
Original Manuscript: January 31, 2001
Published: March 26, 2001
Citation
Yong Xu, Nicusor Iftimia, Huabei Jiang, L. Key, and Marcy Bolster, "Imaging of in vitro and in vivo bones and joints with continuous-wave diffuse optical tomography," Opt. Express 8, 447-451 (2001)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-8-7-447
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References
- S. Colak, M. van der Mark, G. tHooft, J. Hoogenraad, E. van der Linden, F. Kuijpers, "Clinical optical tomography and NIR spectroscopy for breast cancer detection," IEEE J. Sel. Top. Quant. Electron. 5, 1143-1158(1999). [CrossRef]
- V. Ntziachristos, A. Yodh, M. Schnall, B. Chance, "Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement," Proc. Natl. Acad. Sci. USA 97, 2767-2772(2000). [CrossRef] [PubMed]
- H. Jiang, N. Iftimia, J. Eggert, L. Baron, K. Klove, Y. Xu, Y. Yang, T. Pope, "Near-infrared optical imaging of breast," Med. Phys. (in press).
- B. Chance, E. Anday, S. Nioka, S. Zhou, L. Hong, K. Worden, C. Li, T. Murray, Y. Ovetsky, D. Pidikiti, R. Thomas, "A novel method for fast imaging of brain function, non-invasively, with light," Opt. Express 2, 411-423(1998), http://www.opticsexpress.org/oearchive/source/4445.htm [CrossRef] [PubMed]
- V. Prapavat, R. Schuetz, W. Runge, J. Beuthan, G. Muller, "In vivo investigations on the detection of chronical polyarthritis using a cw transillumination method at interphalangeal joints," Proc. SPIE 2626, 360-366(1995). [CrossRef]
- B. Devaraj, M. Takeda, M. Kobayashi, M. Usa, K. Chan, Y. Watanabe, T. Yuasa, T. Akatsuka, M. Yamada, H. Inaba, "In vivo laser computed tomographic imaging of human fingers by coherent detection imaging method using different wavelengths in near infrared region," Appl. Phys. Lett. 69, 3671-3673(1996). [CrossRef]
- M. Zevallos, S. Gayen, B. Das, M. Alrubaiee, R. Alfano, "Picosecond electronic time-gated imaging of bones in tissues," IEEE J. Sel. Top. Quant. Electron. 5, 916-922(1999). [CrossRef]
- A. Klose, A. Hielscher, K. Hanson, J. Beuthan, "Two- and three-dimensional optical tomography of finger joints for diagnostics of rheumatoid arthritis," Proc. SPIE 3566, 151-159 (1998). [CrossRef]
- N. Iftimia, H. Jiang, "Quantitative optical image reconstruction of turbid media using dc measurements," Appl. Opt. 39, 5256-5261 (2000). [CrossRef]
- J. Beuthan, O. Minet, G. Muller, V. Prapavat, "IR-diaphanoscopy in medicine," in Medical Optical Tomography: Functional Imaging and Monitoring (G. Muller, B. Chance, R. Alfano, eds.), pp. 263-282, SPIE Press, 1993.
- V. Prapavat, W. Runge, J. Mans, A. Krause, J. Beuthan, G. Muller, "The development of a finger joint phantom for the optical simulation of early inflammatory rheumatic changes," Biomedizinische Technik 42, 319-326 (1997).
- J. Beuthan, V. Prapavat, R. Naber, O. Minet, G. Muller, "Diagnostic of inflammatory rheumatic diseases with photon density waves," Proc. SPIE 2676, 43-53 (1996). [CrossRef]
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