OSA's Digital Library

Optics Express

Optics Express

  • Editor: J. H. Eberly
  • Vol. 9, Iss. 10 — Nov. 5, 2001
  • pp: 533–545

Topography and volume measurements of the optic nerve using en-face optical coherence tomography

John A. Rogers, Adrian Gh. Podoleanu, George M. Dobre, David A. Jackson, and Fred W. Fitzke  »View Author Affiliations


Optics Express, Vol. 9, Issue 10, pp. 533-545 (2001)
http://dx.doi.org/10.1364/OE.9.000533


View Full Text Article

Enhanced HTML    Acrobat PDF (692 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

A special imaging instrument was developed which can acquire optical coherence tomography (OCT) en-face images from the eye fundus, and simultaneously a confocal image. Using this instrument we illustrate for the first time the application of en-face OCT imaging to produce topography and perform area and volume measurements of the optic nerve. The procedure is compared with the topography, area and volume measurements using a confocal scanning laser ophthalmoscope.

© Optical Society of America

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Research Papers

History
Original Manuscript: August 14, 2001
Published: November 5, 2001

Citation
John Rogers, Adrian Podoleanu, George Dobre, David Jackson, and Frederick Fitzke, "Topography and volume measurements of the optic nerve usingen-face optical coherence tomography," Opt. Express 9, 533-545 (2001)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-9-10-533


Sort:  Journal  |  Reset  

References

  1. R. H. Webb, G. W. Hughes and F. C. Delori, "Confocal scanning laser ophthalmoscope," Appl. Opt. 26, 1492-1499 (1987). [CrossRef] [PubMed]
  2. W. H. Woon, F. W. Fitzke, A. C. Bird and J. Marshall, "Confocal imaging of the fundus using a scanning laser ophthalmoscope," British J. Ophthalmology, 76, 470-474, (1992). [CrossRef]
  3. A. E. Elsner, S. A. Burns, J. J. Weiter, and F. C. Delori, "Infrared imaging of sub- retinal structures in the human ocular fundus," Vision Research 36, 191-205 (1996). [CrossRef] [PubMed]
  4. B. R. Masters, "Three-dimensional confocal microscopy of the human optic nerve in vivo," Opt. Express, 3, 356-359 (1998), http://www.opticsexpress.org/oearchive/source/6295.htm [CrossRef] [PubMed]
  5. Heidelberg Retina Tomograph, Operation Manual, (Heidelberg Engineering GmbH, Heidelberg, 1997).
  6. A. W. Dreher, P. C. Tso and R. N. Weinreb, "Reproducibility of topographic measurements of the normal and glaucomatous optic nerve head with the laser tomographic scanner," American J. Ophthalmology, 111, 221-229 (1994).
  7. F. S. Mikelberg, C. M. Parfitt, N. V. Swindale, S. L. Graham, S. M. Drance and R. Gosine, "Ability of the Heidelberg Retina Tomograph to detect early glaucomatous visual field loss," J. Glaucoma, 4, 242-247 (1995). [CrossRef] [PubMed]
  8. D. U. Bartsch, W.R. Freeman, "Axial intensity distribution analysis of the human retina with a confocal scanning laser tomograph," Exp. Eye Res. 58, 161-173 (1994). [CrossRef] [PubMed]
  9. K. U. Bartz-Schmidt, A. Sengersdorf, P. Esser, P. Walter, R-D. Hilgers and G. K. Kriegsltein, "The cumulative normalised rim/disc area ratio curve," Graefe's Arch Clin Exp. Ophthalmol. 234 227-231 (1996). [CrossRef]
  10. D. Huang, E.A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito and J. G. Fujimoto, "Optical Coherence tomography," Science 254, 1178-1181 (1991). [CrossRef] [PubMed]
  11. J. A. Izaat, M. R. Hee, G. M. Owen, E. A. Swanson and J. G. Fujimoto, "Optical coherence microscopy in scattering media," Opt. Lett., 19, 590-592 (1994). [CrossRef]
  12. C. Puliafito, Optical coherence tomography of ocular diseases, (Thorofare, NJ, SLACK Inc., 1996).
  13. Data sheets of Humphrey Instruments, Optical Coherence Tomography, Humphrey Instruments, (2992 Alvarado St., San Leandro CA 94577, 1996).
  14. J. S. Schuman, T. Pedut-Kloizman, E. Hertzmark, M. R. Hee, J. R. Walkins, J. G. Cooker, C. A. Puliafito, J. G. Fujimoto, E. A. Swanson, "Reproducibility of Nerve Fiber Layer Thickness Measurements Using Optical Coherence tomography," Ophthalmology, 103, 1889-1898 (1996).
  15. A. Gh. Podoleanu, M. Seeger, G. M. Dobre, D. J. Webb, D. A. Jackson and F. Fitzke "Transversal and longitudinal images from the retina of the living eye using low coherence reflectometry," J. Biomed Opt. 3, 12-20 (1998). [CrossRef]
  16. A. Gh. Podoleanu and D. A. Jackson, "Noise Analysis of a combined optical coherence tomography and confocal scanning ophthalmoscope," Appl. Opt. 38, 2116-2127 (1999). [CrossRef]
  17. A. Gh. Podoleanu, J. A. Rogers, D. A. Jackson, S. Dunne, "Three dimensional OCT images from retina and skin," Opt. Express, 7, 292-298, (2000), http://www.opticsexpress.org/framestocv7n9.htm [CrossRef] [PubMed]
  18. R. N. Weinreb, Lusky, D-U Bartsch and D. Morsman, "Effect of repetitive imaging on topographic measurements of the optic nerve head," Arch Ophthalmol. 111, 636-638 (1993). [CrossRef] [PubMed]
  19. W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, .S. Schuman, J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nature Medicine 7, 502-507, (2001). [CrossRef] [PubMed]
  20. D. S. Chauhan and J. Marshall, "The Interpretation of Optical Coherence Tomography Images of the Retina," Investigative Ophthalmology 40, 2332-2342 (1999).
  21. C. K. Hitzenberger, A. Baumgartner, A. F. Fercher, "Dispersion induced multiple signal peak splitting in partial coherence interferometry," Opt. Commun. 154, 179-185 (1998). [CrossRef]
  22. R. H. Webb, "Scanning laser ophthalmoscope", in Noninvasive diagnostic techniques in ophthalmology, B. R. Masters ed, (Springer-Verlag, New York, 1990), pp. 438-450. [CrossRef]
  23. American National Standard for the Safe Use of Lasers: ANSI Z 136.1, (Laser Institute of America, New York, NY, 1993).
  24. A. Gh.Podoleanu, J. A. Rogers, D. A. Jackson, "OCT En-face Images from the retina with adjustable depth resolution in real time," IEEE Journal of Selected Topics in Quantum Electron. 5, 1176-1184 (1999). [CrossRef]
  25. F. C. Delori and K. P. Pflibsen, 'Spectral reflectance of the human ocular fundus," Appl. Opt. 28, 1061-1077 (1989). [CrossRef] [PubMed]
  26. J. van de Kraats,. T.T.J.M.Berendschot, D. van Norren, D, "The pathways of light measured in fundus reflectometry," Vision Res. 35, 2229-2247 (1996). [CrossRef]
  27. Elsner AE, Moraes L, Beausencourt E, et al., "Scanning laser reflectometry of retinal and subretinal tissues," Opt. Express 6, 243-250 (2000) http://www.opticsexpress.org/oearchive/source/21766.htm [CrossRef] [PubMed]
  28. A.E. Elsner, M. Miura, S.A. Burns, E. Beausencourt, C. Kunze, L.M. Kelley, , J.P. Walker, G.L. Wing, P.A. Raskauskas, , D.C. Fletcher, Q. Zhou and A.W. Dreher, "Multiply scattered light tomography and confocal imaging: detecting neovascularization in age-related macular degeneration," Opt. Express 7, 95-106 (2001), http://www.opticsexpress.org/oearchive/source/22805.htm [CrossRef]
  29. E. Beausencourt, A. E. Elsner, M. E. Hartnett, C. L. Trempe, "Quantitative analysis of macular holes with scanning laser tomography," Ophthalmology 104, 2018-2029 (1997). [PubMed]
  30. C. Hudson, S. J. Charles, J. G. Flanagan, A. K. Brahma, G. S. Turner and D. McLeod, "Objective morphological assessment of macular hole surgery by scanning laser tomography," British KJ. Ophthalmol. 81, 107-116 (1997). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Supplementary Material


» Media 1: MOV (999 KB)     

« Previous Article

OSA is a member of CrossRef.

CrossCheck Deposited