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Optics Express

Optics Express

  • Editor: J. H. Eberly
  • Vol. 9, Iss. 6 — Sep. 10, 2001
  • pp: 272–286

Three-dimensional optical tomography of hemodynamics in the human head

Avraham Y. Bluestone, Gassan Abdoulaev, Christoph H. Schmitz, Randall L. Barbour, and Andreas H. Hielscher  »View Author Affiliations

Optics Express, Vol. 9, Issue 6, pp. 272-286 (2001)

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We report on the first three-dimensional, volumetric, tomographic localization of vascular reactivity in the brain. To this end we developed a model-based iterative image reconstruction scheme that employs adjoint differentiation methods to minimize the difference between measured and predicted data. The necessary human-head geometry and optode locations were determined with a photogrammetric method. To illustrate the performance of the technique, the three-dimensional distribution of changes in the concentration of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin during a Valsalva maneuver were visualized. The observed results are consistent with previously reported effects concerning optical responses to hemodynamic perturbations.

© Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Research Papers

Original Manuscript: July 27, 2001
Published: September 10, 2001

Avraham Bluestone, Gassan Abdoulaev, Christoph Schmitz, Randall Barbour, and Andreas Hielscher, "Three-dimensional optical tomography of hemodynamics in the human head," Opt. Express 9, 272-286 (2001)

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