OSA's Digital Library

Optics Express

Optics Express

  • Editor: J. H. Eberly
  • Vol. 9, Iss. 8 — Oct. 8, 2001
  • pp: 417–427

Study of local cerebral hemodynamics by frequency-domain near-infrared spectroscopy and correlation with simultaneously acquired functional magnetic resonance imaging

Vladislav Toronov, Andrew Webb, Jee Hyun Choi, Martin Wolf, Larisa Safonova, Ursula Wolf, and Enrico Gratton  »View Author Affiliations

Optics Express, Vol. 9, Issue 8, pp. 417-427 (2001)

View Full Text Article

Enhanced HTML    Acrobat PDF (332 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



The aim of our study was to explore the possibility of detecting hemodynamic changes in the brain using the phase of the intensity modulated optical signal. To obtain optical signals with the highest possible signal-to-noise ratio, we performed a series of simultaneous NIRS-fMRI measurements, with subsequent correlation of the time courses of both measurements. The cognitive paradigm used arithmetic calculations, with optical signals acquired with sensors placed on the forehead. Measurements were done on seven healthy subjects. In five subjects we demonstrated correlation between the hemodynamic signals obtained using NIRS and BOLD fMRI. In four subjects correlation was found for the hemodynamic signal obtained using the phase of the intensity modulated signal.

© Optical Society of America

OCIS Codes
(110.7050) Imaging systems : Turbid media
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Research Papers

Original Manuscript: August 20, 2001
Published: October 8, 2001

Vladislav Toronov, Andrew Webb, Jee Hyun Choi, Martin Wolf, Larisa Safonova, Ursula Wolf, and Enrico Gratton, "Study of local cerebral hemodynamics by frequency-domain near-infrared spectroscopy and correlation with simultaneously acquired functional magnetic resonance imaging," Opt. Express 9, 417-427 (2001)

Sort:  Journal  |  Reset  


  1. E. Gratton, W. W. Mantulin, vande M. J. Ven, J. B. Fishkin, M. B. Maris, and B. Chance, "The possibility of a near-infrared imaging system using frequency-domain methods," Proc. Third Intl. Conf.: Peace through Mind/ Brain Science, 183-189, Hamamatsu City, Japan (1990)
  2. M. S. Patterson, J. D. Moulton, B. C. Wilson , "Frequency-domain reflectance for the determination of the scattering and absorption properties of tissue," Appl. Opt. 30, 4474-4476 (1991) [CrossRef]
  3. B. Tromberg, L. O. Svaasand, T. Tsay, R. C. Haskell, "Properties of photon density waves in multiple-scattering media," Appl. Opt. 32, 607-616 (1993) [CrossRef] [PubMed]
  4. M. Firbank, E. Okada, D. T. Delpy, "A theoretical study of the signal contribution of regions of the adult head to near-infrared spectroscopy studies of visual evoked responses," Neuroimage 8, 69-78 (1998) [CrossRef] [PubMed]
  5. T. O. McBride, B. W. Pogue, U. L. Osterberg, K. D. Paulsen, "Separation of absorption and scattering heterogeneities in NIR tomographic imaging of tissue," in Biomedical Topical Meetings, OSA Technical Digest (Optical Society of America, Washington DC, 2000), pp.339-341
  6. B. Chance, Z. Zhuang, C. Unah, C. Alter, L. Lipton, "Cognition-activated low-frequency modulation of light absorption in human brain," Proc. Natl. Acad. Sci. U S A. 90, 3770-4 (1993) [CrossRef] [PubMed]
  7. B. Chance, E. Anday, S. Nioka, S. Zhou, L. Hong, K. Worden, C. Li, T. Murray, Y. Ovetsky, D. Pidikiti and R. Thomas, "A novel method for fast imaging of brain function, non-invasively, with light," Opt. Express 2, 411-423 (1998) http://www.opticsexpress.org/oearchive/source/4445.htm [CrossRef] [PubMed]
  8. A. Villringer, B. Chance, Non-invasive optical spectroscopy and imaging of human brain function, Trends Neurosci. 20, 435-42 (1997)
  9. V. Toronov, M. Wolf, A. Michalos, and E. Gratton, "Analysis of cerebral hemodynamic fluctuations measured simultaneously by magnetic resonance imaging and near-infrared spectroscopy," WA5, Proc. OSA Technical Digest, Biomedical Topical Meeting (2000)
  10. V. Toronov, A. Webb, J. H. Choi, M. Wolf, A. Michalos, E. Gratton E., and D. Hueber, "Investigation of human brain hemodynamics by simultaneous near-infrared spectroscopy and functional magnetic resonance imaging," Med. Phys. 28, 521-527(2001) [CrossRef] [PubMed]
  11. S. Wray, M. Cope, D.T. Delpy, J. S. Wyatt, and E. O. Reynolds, "Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation," Biochim. Biophys. Acta 933, 184-192 (1988). [CrossRef] [PubMed]
  12. S. Fantini, M. A. Franceschini and E. Gratton., "Semi-infinite geometry boundary problem for light migration in highly scattering media: a frequency-domain study in the diffusion approximation," J. Opt. Soc. Am. B 11, 2128-2138 (1994). [CrossRef]
  13. T. Durduran, A.G. Yodh, B. Chance, and D.A. Boas, "Does the photon-diffusion coefficient depend on absorption?," J. Opt. Soc. Am. A 14, 3358-3365 (1997). [CrossRef]
  14. D. J. Durian, "The diffusion coefficient depends on absorption," Opt. Lett. 23, 1502-1504 (1998). [CrossRef]
  15. M. Bassani, F. Martelli, G. Zaccanti, and D. Contini, "Independence of the diffusion coefficient from absorption: experimental and numerical evidence," Opt. Lett. 22, 853-855 (1997). [CrossRef] [PubMed]
  16. V. Toronov, M. A. Franceschini, M. Filiaci, S. Fantini, M. Wolf, A. Michalos, and E. Gratton, "Near-infrared study of fluctuations in cerebral hemodynamics during rest and motor stimulation: temporal analysis and spatial mapping," Med. Phys. 27, 801-15 (2000). [CrossRef] [PubMed]
  17. A. Maki, Y. Yamashita, Y. Ito, E. Watanabe, Y. Mayangi, and H. Koizumi, "Spatial and temporal analysis of human motor activity using non-invasive NIR topography," Med. Phys. 22, 1997-2005 (1995). [CrossRef] [PubMed]
  18. L. A. Paunescu, A. Michalos, J. H. Choi, U. Wolf, M. Wolf, and E. Gratton, "In vitro correlation between reduced scattering coefficient and hemoglobin concentration of human blood determined by near-infrared spectroscopy," Proceedings of SPIE 4050, 319-325 (2001). [CrossRef]
  19. S. Fantini, D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, M. R. Stankovic, "Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy," Phys. Med. Biol. 44, 1543-1563 (1999). [CrossRef]
  20. I. Miller and J. E. Freund, Probability and Statistics for Engineers, Prentice-Hall, (1977).
  21. K. J. Friston, P. Jezzard, and R. Turner, "Analysis of Functional MRI Time-Series," Human Brain Mapping 1, 153-171 (1994). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1. Fig. 2. Fig. 3.
Fig. 4.

« Previous Article

OSA is a member of CrossRef.

CrossCheck Deposited