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Optics Express

Optics Express

  • Editor: J. H. Eberly
  • Vol. 9, Iss. 8 — Oct. 8, 2001
  • pp: 417–427

Study of local cerebral hemodynamics by frequency-domain near-infrared spectroscopy and correlation with simultaneously acquired functional magnetic resonance imaging

Vladislav Toronov, Andrew Webb, Jee Hyun Choi, Martin Wolf, Larisa Safonova, Ursula Wolf, and Enrico Gratton  »View Author Affiliations


Optics Express, Vol. 9, Issue 8, pp. 417-427 (2001)
http://dx.doi.org/10.1364/OE.9.000417


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Abstract

The aim of our study was to explore the possibility of detecting hemodynamic changes in the brain using the phase of the intensity modulated optical signal. To obtain optical signals with the highest possible signal-to-noise ratio, we performed a series of simultaneous NIRS-fMRI measurements, with subsequent correlation of the time courses of both measurements. The cognitive paradigm used arithmetic calculations, with optical signals acquired with sensors placed on the forehead. Measurements were done on seven healthy subjects. In five subjects we demonstrated correlation between the hemodynamic signals obtained using NIRS and BOLD fMRI. In four subjects correlation was found for the hemodynamic signal obtained using the phase of the intensity modulated signal.

© Optical Society of America

OCIS Codes
(110.7050) Imaging systems : Turbid media
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Research Papers

History
Original Manuscript: August 20, 2001
Published: October 8, 2001

Citation
Vladislav Toronov, Andrew Webb, Jee Hyun Choi, Martin Wolf, Larisa Safonova, Ursula Wolf, and Enrico Gratton, "Study of local cerebral hemodynamics by frequency-domain near-infrared spectroscopy and correlation with simultaneously acquired functional magnetic resonance imaging," Opt. Express 9, 417-427 (2001)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-9-8-417


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