OSA's Digital Library

Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Vol. 21, Iss. 2 — Jan. 15, 1996
  • pp: 158–160

Fluorescence lifetime imaging in turbid media

M. A. O’Leary, D. A. Boas, X. D. Li, B. Chance, and A. G. Yodh  »View Author Affiliations


Optics Letters, Vol. 21, Issue 2, pp. 158-160 (1996)
http://dx.doi.org/10.1364/OL.21.000158


View Full Text Article

Enhanced HTML    Acrobat PDF (1539 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

The lifetime of a fluorophore generally varies in different environments, making the molecule a sensitive indicator of tissue oxygenation, pH, and glucose. However, lifetime measurements are complicated when the fluorophore is embedded in an optically thick, highly scattering medium such as human tissue. We formulate the inverse problem for fluorescence lifetime tomography using diffuse photon density waves, and we demonstrate the technique by deriving spatial images of heterogeneous fluorophore distribution and lifetime, using simulated measurements in heterogeneous turbid media.

© 1996 Optical Society of America

History
Original Manuscript: August 15, 1995
Published: January 15, 1996

Citation
M. A. O’Leary, D. A. Boas, X. D. Li, B. Chance, and A. G. Yodh, "Fluorescence lifetime imaging in turbid media," Opt. Lett. 21, 158-160 (1996)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-21-2-158

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited