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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Vol. 22, Iss. 14 — Jul. 15, 1997
  • pp: 1119–1121

Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography

Zhongping Chen, Thomas E. Milner, Shyam Srinivas, Xiaojun Wang, Arash Malekafzali, Martin J. C. van Gemert, and J. Stuart Nelson  »View Author Affiliations


Optics Letters, Vol. 22, Issue 14, pp. 1119-1121 (1997)
http://dx.doi.org/10.1364/OL.22.001119


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Abstract

We report the development of an optical technique for noninvasive imaging of in vivo blood flow dynamics and tissue structures with high spatial resolution (2–10 µm) in biological systems. The technique is based on optical Doppler tomography (ODT), which combines Doppler velocimetry with optical coherence tomography to measure blood flow velocity at discrete spatial locations. The exceptionally high resolution of ODT permits noninvasive in vivo imaging of both blood microcirculation and tissue structures surrounding the vessel, which has significance for biomedical research and clinical applications. Tomographic imaging of in vivo blood flow velocity in the chick chorioallantoic membrane and in rodent skin is demonstrated.

© 1997 Optical Society of America

Citation
Zhongping Chen, Thomas E. Milner, Shyam Srinivas, Xiaojun Wang, Arash Malekafzali, Martin J. C. van Gemert, and J. Stuart Nelson, "Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography," Opt. Lett. 22, 1119-1121 (1997)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-22-14-1119


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References

  1. Y. Yamada, M. Matsumura, S. Kyo, and R. Omoto, Am. J. Cardiol. 75, 161 (1995).
  2. J. V. Chapman, in Noninvasive Evaluation of Hemodynamics in Congenital Heart Disease, J. V. Chapman G. R. Sutherland, eds. (Kluwer, Dordrecht, The Netherlands, 1990), Chap. 2, pp. 57.
  3. W. J. Manning, W. Li, and R. R. Edelman, N. Engl. J. Med. 328, 828 (1993).
  4. R. F. Bonner R. Nossal, in Laser-Doppler Blood Flowmetry, A. P. Shepherd and P. A. Oberg, eds. (Kluwer, Dordrecht, The Netherlands, 1990), Chap. 2, pp. 17.
  5. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991).
  6. A. F. Fercher, and J. Biomed. Opt. 1, 157 (1996).
  7. J. A. Izatt, M. R. Hee, G. M. Owen, E. A. Swanson, and J. G. Fujimoto, Opt. Lett. 19, 590 (1994).
  8. Z. Chen, T. E. Milner, D. Dave, and J. S. Nelson, Opt. Lett. 22, 64 (1997).
  9. X. J. Wang, T. E. Milner, Z. Chen, and J. S. Nelson, Appl. Opt. 36, 144 (1997).
  10. X. J. Wang, T. E. Milner, and J. S. Nelson, Opt. Lett. 20, 1337 (1995).
  11. J. G. Fujimoto, M. E. Brezinski, G. J. Tearney, S. A. Poppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson, Nat. Med. 1, 970 (1995).
  12. S. Kimel, L. O. Svaasand, M. Hammer-Wilson, M. J. Schell, T. E. Milner, J. S. Nelson, M. W. Berns, and J. Invest. Dermatol. 103, 693 (1994).
  13. P. C. Neligan, Microsurgery 14, 162 (1993).
  14. Z. B. M. Niazi, T. J. H. Essex, R. Papini, D. Scott, N. R. Mclean, and M. J. M. Black, Burns 19, 485 (1993).
  15. M. Korbelik G. Krosl, and Br. J. Cancer 70, 604 (1994).
  16. Z. Chen, T. E. Milner, S. Srinivas, and J. S. Nelson, “Optical Doppler tomography: in vivo blood flow dynamics following pharmacologic intervention and photodynamic therapy,” Photochem. Photobiol. (to be published).

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