OSA's Digital Library

Optics Letters

Optics Letters


  • Vol. 24, Iss. 15 — Aug. 1, 1999
  • pp: 1050–1052

Imager that combines near-infrared diffusive light and ultrasound

Q. Zhu, T. Durduran, V. Ntziachristos, M. Holboke, and A. G. Yodh  »View Author Affiliations

Optics Letters, Vol. 24, Issue 15, pp. 1050-1052 (1999)

View Full Text Article

Acrobat PDF (204 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



We introduce an imaging technique that combines complementary features of ultrasound and near-infrared diffusive light imaging. We achieve the combined technology experimentally by mounting an ultrasound array together with multiple laser source and optical detector fibers upon a hand-held probe. The technique is demonstrated with tissue phantoms wherein both acoustic and optical sensors image the volume underneath the probe. Coregistration of acoustic and optical images is achieved with an accuracy of 0.27±0.20cm, approximately half of the image pixel size of our prototype. Accurate determination of target optical absorption is also achieved by use of image segmentation on the ultrasound reconstruction. The combined technique may provide improved breast-cancer detection sensitivity and specificity.

© 1999 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3830) Medical optics and biotechnology : Mammography
(170.5280) Medical optics and biotechnology : Photon migration
(170.7170) Medical optics and biotechnology : Ultrasound

Q. Zhu, T. Durduran, V. Ntziachristos, M. Holboke, and A. G. Yodh, "Imager that combines near-infrared diffusive light and ultrasound," Opt. Lett. 24, 1050-1052 (1999)

Sort:  Author  |  Year  |  Journal  |  Reset


  1. T. A. Stavros, D. Thickman, and C. Rapp, Radiology 196, 123 (1995).
  2. B. B. Goldberg, J. B. Liu, and F. Forsberg, Ultrasound Med. Biol. 20, 319 (1994).
  3. M. A. Franceschini, K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, M. Seeber, P. M. Schlag, and M. Kashke, Proc. Natl. Acad. Sci. USA 94, 6468 (1997).
  4. J. B. Fishkin, O. Coquoz, E. R. Anderson, M. Brenner, and B. J. Tromberg, Appl. Opt. 36, 10 (1997).
  5. T. L. Troy, D. L. Page, and E. M. Sevick-Muraca, J. Biomed. Opt. 1, 342 (1996).
  6. R. J. Grable, D. P. Rohler, and S. Kla, Proc. SPIE 2979, 197 (1997).
  7. B. Chance, S. Nioka, S. Zhou, and E. Conant, “Simple, fast, breast-tumor hypoxia imager,” Proc. SPIE 3597 (to be published).
  8. A. Yodh and B. Chance, Phys. Today 48(3), 34 (1995).
  9. Q. Zhu, D. Sullivan, B. Chance, and T. Dambro, IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46, 665 (1999).
  10. B. J. Tromberg, University of California, Irvine, Irvine, Calif. 92612 (personal communication, 1999).
  11. L. Wang, S. L. Steven, and X. Zhao, Opt. Lett. 20, 629 (1995); L. Wang and G. Ku, Opt. Lett. 23, 975 (1998).
  12. S. Leveque, A. C. Boccara, M. Lebec, and H. Saint-Jalmes, Opt. Lett. 24, 181 (1999).
  13. R. M. Danen, Y. Wang, X. D. Li, W. S. Thayer, and A. G. Yodh, Photochem. Photobiol. 67, 33 (1998).
  14. Y. Yao, Y. Wang, Y. Pei, W. Zhu, and R. L. Barbour, J. Opt. Soc. Am. A 14, 325 (1997).
  15. N. Ramanujam, C. Du, H. Y. Ma, and B. Chance, Rev. Sci. Instrum. 69, 3042 (1998).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited