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Optics Letters

Optics Letters


  • Vol. 27, Iss. 16 — Aug. 15, 2002
  • pp: 1412–1414

Biosensing based on two-photon fluorescence measurements through optical fibers

Jing Yong Ye, Mon Thiri Myaing, Theodore B. Norris, Thommey Thomas, and James Baker, Jr.  »View Author Affiliations

Optics Letters, Vol. 27, Issue 16, pp. 1412-1414 (2002)

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We have performed two-photon fluorescence detection in a new scheme in which femtosecond laser pulses were delivered thorugh an optical fiber for nonlinear excitation and the emitted fluorescence was collected through the same fiber. Single-mode fibers were determined to give higher detection efficiency than multimode fibers, consistent with theoretical considerations. The utility of fiber-optic sensing based on two-photon fluorescence detection was proved by an experiment that measured the uptake of a targeted drug delivery agent into cultured cancer cells.

© 2002 Optical Society of America

OCIS Codes
(060.2370) Fiber optics and optical communications : Fiber optics sensors
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(190.4180) Nonlinear optics : Multiphoton processes

Jing Yong Ye, Mon Thiri Myaing, Theodore B. Norris, Thommey Thomas, and James Baker, Jr., "Biosensing based on two-photon fluorescence measurements through optical fibers," Opt. Lett. 27, 1412-1414 (2002)

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