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Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Vol. 28, Iss. 20 — Oct. 15, 2003
  • pp: 1915–1917

Dual-axes confocal microscopy with post-objective scanning and low-coherence heterodyne detection

Thomas D. Wang, Christopher H. Contag, Michael J. Mandella, NingY. Chan, and Gordon S. Kino  »View Author Affiliations


Optics Letters, Vol. 28, Issue 20, pp. 1915-1917 (2003)
http://dx.doi.org/10.1364/OL.28.001915


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Abstract

We present a dual-axes confocal microscope that employs postobjective scanning and low-coherence heterodyne detection to collect vertical cross-sectional images from biological tissue with high axial resolution, reduced noise from scattered light, deep tissue penetration, and a large dynamic range. This architecture can be scaled down to millimeter dimensions with microelectromechanical systems technology for performance of in vivo optical biopsy.

© 2003 Optical Society of America

OCIS Codes
(110.0180) Imaging systems : Microscopy
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(120.4570) Instrumentation, measurement, and metrology : Optical design of instruments
(170.1790) Medical optics and biotechnology : Confocal microscopy
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.4730) Medical optics and biotechnology : Optical pathology

Citation
Thomas D. Wang, Christopher H. Contag, Michael J. Mandella, NingY. Chan, and Gordon S. Kino, "Dual-axes confocal microscopy with post-objective scanning and low-coherence heterodyne detection," Opt. Lett. 28, 1915-1917 (2003)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-28-20-1915


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References

  1. T. D. Wang, M. J. Mandella, C. H. Contag, and G. S. Kino, Opt. Lett. 28, 414 (2003).
  2. R. H. Webb and F. Rogomentich, Appl. Opt. 38, 4870 (1999).
  3. S. Lindek, C. Cremer, and E. H. K. Stelzer, Appl. Opt. 35, 126 (1996).
  4. J. M. Crawford, in Robbins Pathologic Basis of Disease, R. S. Cotran, ed., 6th ed. (Saunders, Philadelphia, Pa., 1999), p. 781.
  5. N. Iftimia, B. E. Bouma, and G. J. Tearney, J. Biomed. Opt. 8, 260 (2003).

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