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Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Vol. 28, Iss. 21 — Nov. 1, 2003
  • pp: 2070–2072

Metabolism-enhanced tumor localization by fluorescence imaging: in vivo animal studies

Y. Chen, G. Zheng, Z. H. Zhang, D. Blessington, M. Zhang, H. Li, Q. Liu, L. Zhou, X. Intes, S. Achilefu, and B. Chance  »View Author Affiliations


Optics Letters, Vol. 28, Issue 21, pp. 2070-2072 (2003)
http://dx.doi.org/10.1364/OL.28.002070


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Abstract

We present a high-sensitivity near-infrared optical imaging system for noninvasive cancer detection and localization based on molecularly labeled fluorescent contrast agents. This frequency-domain system utilizes the interferencelike pattern of diffuse photon density waves to achieve high detection sensitivity and localization accuracy for the fluorescent heterogeneity embedded inside the scattering media. A two-dimensional localization map is obtained through reflectance probe geometry and goniometric reconstruction. In vivo measurements with a tumor-bearing mouse model by use of the novel Cypate-mono-2-deoxy-glucose fluorescent contrast agent, which targets the enhanced tumor glycolysis, demonstrate the feasibility of detection of a 2-cm-deep subsurface tumor in the tissuelike medium, with a localization accuracy within 2–3 mm.

© 2003 Optical Society of America

OCIS Codes
(110.5100) Imaging systems : Phased-array imaging systems
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5270) Medical optics and biotechnology : Photon density waves
(300.2530) Spectroscopy : Fluorescence, laser-induced

Citation
Y. Chen, G. Zheng, Z. H. Zhang, D. Blessington, M. Zhang, H. Li, Q. Liu, L. Zhou, X. Intes, S. Achilefu, and B. Chance, "Metabolism-enhanced tumor localization by fluorescence imaging: in vivo animal studies," Opt. Lett. 28, 2070-2072 (2003)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-28-21-2070

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