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Optics Letters

Optics Letters


  • Vol. 28, Iss. 21 — Nov. 1, 2003
  • pp: 2076–2078

Enhanced sensitivity and spatial resolution for in vivo imaging with low-level light-emitting probes by use of biocompatible chemical agents

Yonghong He, Ruikang K. Wang, and Da Xing  »View Author Affiliations

Optics Letters, Vol. 28, Issue 21, pp. 2076-2078 (2003)

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We describe a technique that uses biocompatible chemical agents to enhance both the sensitivity and the resolution of in vivo imaging with low-level light-emitting probes. We demonstrate experimentally, with chemiluminescence (CL) imaging in vitro as an example, that the detected intensity of CL from treated 3-mm-thick skin tissue is approximately fivefold stronger than that from untreated skin. The spatial resolution correspondingly increases approximately threefold.

© 2003 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence

Yonghong He, Ruikang K. Wang, and Da Xing, "Enhanced sensitivity and spatial resolution for in vivo imaging with low-level light-emitting probes by use of biocompatible chemical agents," Opt. Lett. 28, 2076-2078 (2003)

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  1. R. Paulmurugan, Y. Umezawa, and S. S. Gambhir, Proc. Natl. Acad. Sci. USA 99, 15608 (2002).
  2. C. E. O’Connell-Rodwell, S. M. Burns, M. H. Bachmann, and C. H. Contag, Trends Biotechnol. 20, 19 (2002).
  3. B. Laxman, D. E. Hall, M. S. Bhojani, C. A. Hamstra, T. L. Chenevert, B. D. Ross, and A. Rehemtulla, Proc. Natl. Acad. Sci. USA 99, 16551 (2002).
  4. J. Hardy, M. Edinger, M. H. Bachmann, R. S. Negrin, C. G. Fathman, and C. H. Contag, Exp. Hematol. 29, 1353 (2001).
  5. Y. He, D. Xing, G. Yan, and K. Ueda, Cancer Lett. 182, 141 (2002).
  6. H. Yasui and H. Sakurai, Biochem. Biophys. Res. Commun. 269, 131 (2000).
  7. L. V. Wang and Q. Shen, Opt. Lett. 23, 561 (1998).
  8. Q. Shen and L. V. Wang, Appl. Opt. 38, 246 (1999).
  9. M. Kobayashi, M. Takeda, T. Sato, Y. Yamazaki, K. Kaneko, K. Ito, H. Kato, and H. Inaba, Neurosci. Res. 34, 103 (1999).
  10. B. W. Rice, M. D. Cable, and M. B. Nelson, J. Biomed. Opt. 6, 432 (2001).
  11. V. V. Tuchin, I. L. Maksimova, D. A. Zimnyakov, I. L. Kon, A. H. Mavlutov, and A. A. Mishin, J. Biomed. Opt. 2, 401 (1997).
  12. G. Vargas, E. K. Chan, J. K. Barton, H. G. Rylander, and A. J. Welch, Lasers Surg. Med. 24, 133 (1999).
  13. R. K. Wang, X. Xu, and V. V. Tuchin, J. B. Elder, J. Opt. Soc. Am. B 18, 948 (2001).
  14. R. K. Wang and J. B. Elder, Laser Surg. Med. 30, 201 (2002).
  15. H. Liu, B. Beauvoit, M. Kimura, and B. Chance, J. Biomed. Opt. 1, 200 (1996).
  16. R. K. Wang and V. V. Tuchin, J. X-Ray Sci. Technol. 10, 167 (2002).
  17. V. V. Tuchin, X. Xu, and R. K. Wang, Appl. Opt. 41, 258 (2002).
  18. A. Navas Díaz, F. García Sanchez, and J. A. González García, Anal. Chim. Acta 327, 161 (1996).

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