OSA's Digital Library

Optics Letters

Optics Letters


  • Vol. 28, Iss. 22 — Nov. 15, 2003
  • pp: 2204–2206

Effect of surface roughness on determination of bulk tissue optical parameters

Xiaoyan Ma, Jun Qing Lu, and Xin-Hua Hu  »View Author Affiliations

Optics Letters, Vol. 28, Issue 22, pp. 2204-2206 (2003)

View Full Text Article

Acrobat PDF (840 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



Monte Carlo simulations have been conducted to investigate the effect of surface roughness on the inverse determination of bulk optical parameters. Results show that μs , μa , and g can be overestimated by an order of magnitude for thin slab tissue samples with a moderate index mismatch at the interfaces if typical surface roughness is neglected. Measurements of Intralipid samples between glass windows with smooth and rough surfaces have been carried out and agreement was found between the numerical and the experimental data. This study suggests that the surface roughness should be taken into account for both in vitro and in vivo determination of bulk tissue optical parameters.

© 2003 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.4730) Medical optics and biotechnology : Optical pathology
(290.5880) Scattering : Scattering, rough surfaces

Xiaoyan Ma, Jun Qing Lu, and Xin-Hua Hu, "Effect of surface roughness on determination of bulk tissue optical parameters," Opt. Lett. 28, 2204-2206 (2003)

Sort:  Author  |  Year  |  Journal  |  Reset


  1. B. C. Wilson and G. Adam, Med. Phys. 10, 824 (1983).
  2. R. Graaff, A. C. M. Dassel, M. H. Koelink, F. F. M. de Mul, J. G. Aarnoudse, and W. G. Zijlstra, Appl. Opt. 32, 435 (1993).
  3. L. Wang, S. L. Jacques, and L. Zheng, Comput. Methods Programs Biomed. 47, 131 (1995).
  4. Z. Song, K. Dong, X. H. Hu, and J. Q. Lu, Appl. Opt. 38, 2944 (1999).
  5. T. J. Farrell, M. S. Patterson, and B. Wilson, Med. Phys. 19, 879 (1992).
  6. V. G. Peters, D. R. Wyman, M. S. Patterson, and G. L. Frank, Phys. Med. Biol. 35, 1317 (1990).
  7. J. F. Beek, H. J. van Staveren, P. Posthumus, H. J. Sterenborg, and M. J. van Gemert, Phys. Med. Biol. 42, 2263 (1997).
  8. Y. Du, X. H. Hu, M. Cariveau, X. Ma, G. W. Kalmus, and J. Q. Lu, Phys. Med. Biol. 46, 167 (2001).
  9. C. R. Simpson, M. Kohl, M. Essenpreis, and M. Cope, Phys. Med. Biol. 43, 2465 (1998).
  10. J. W. Pickering, S. A. Prahl, N. Vanwieringen, J. F. Beek, H. J. C. M. Sterenborg, and M. J. C. Vangemert, Appl. Opt. 32, 399 (1993).
  11. T. L. Troy, D. L. Page, and E. M. Sevick-Muraca, J. Biomed. Opt. 1, 342 (1996).
  12. G. Zonios, J. Bykowski, and N. Kollias, J. Invest. Dermatol. 117, 1452 (2001).
  13. J. Q. Lu, X. H. Hu, and K. Dong, Appl. Opt. 39, 5890 (2000).
  14. S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. van Gemert, Lasers Surg. Med. 12, 510 (1992).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited