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Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Vol. 30, Iss. 17 — Sep. 1, 2005
  • pp: 2272–2274

In vivo brain imaging using a portable 3.9 gram two-photon fluorescence microendoscope

Benjamin A. Flusberg, Juergen C. Jung, Eric D. Cocker, Erik P. Anderson, and Mark J. Schnitzer  »View Author Affiliations


Optics Letters, Vol. 30, Issue 17, pp. 2272-2274 (2005)
http://dx.doi.org/10.1364/OL.30.002272


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Abstract

We introduce a compact two-photon fluorescence microendoscope based on a compound gradient refractive index endoscope probe, a DC micromotor for remote adjustment of the image plane, and a flexible photonic bandgap fiber for near distortion-free delivery of ultrashort excitation pulses. The imaging head has a mass of only 3.9 g and provides micrometer-scale resolution. We used portable two-photon microendoscopy to visualize hippocampal blood vessels in the brains of live mice.

© 2005 Optical Society of America

OCIS Codes
(110.2350) Imaging systems : Fiber optics imaging
(110.2760) Imaging systems : Gradient-index lenses
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.2520) Medical optics and biotechnology : Fluorescence microscopy
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5810) Medical optics and biotechnology : Scanning microscopy

Citation
Benjamin A. Flusberg, Juergen C. Jung, Eric D. Cocker, Erik P. Anderson, and Mark J. Schnitzer, "In vivo brain imaging using a portable 3.9 gram two-photon fluorescence microendoscope," Opt. Lett. 30, 2272-2274 (2005)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-30-17-2272

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