Noninvasive in vivo functional optical imaging of the intact retina is demonstrated by using high-speed, ultrahigh-resolution optical coherence tomography (OCT). Imaging was performed with $2.8\mu \mathrm{m}$ resolution at a rate of 24,000 axial scans per second. A white-light stimulus was applied to the dark-adapted rat retina, and the average reflectivities from different intraretinal layers were monitored as a function of time. A 10%–15% increase in the average amplitude reflectance of the photoreceptor outer segments was observed in response to the stimulus. The spatial distribution of the change in the OCT signal is consistent with an increase in backscatter from the photoreceptor outer segments. To our knowledge, this is the first in vivo demonstration of OCT functional imaging in the intact retina.

© 2006 Optical Society of America

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

Related Journal Articles

• Three-dimensional tomographic reconstruction of an absorptive perturbation with diffuse photon density waves (JOSAA)
• Theory of a fixed scatterer embedded in a turbid medium: numerical results (JOSAA)
• Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity (OL)
• Functional optical coherence tomography for detecting neural activity through scattering changes (OL)
• Long-wavelength optical coherence tomography at 1.7 μm for enhanced imaging depth (OE)

Related Conference Papers

• Pump-Probe Scheme for Optical Coherence Tomography Using Indocyanine Green Mixed with Albumin or Human Plasma
• Compact ultrahigh resolution OCT system for real-time in vivo imaging
• Non-linear interferometric vibrational imaging
• Simulation of 3D light propagation in a layered head model including a clear CSF layer
• Reconstructed images for oxy and deoxy hemoglobin for a phantom with varied local oxygenation using optical CT