OSA's Digital Library

Optics Letters

Optics Letters


  • Editor: Anthony J. Campillo
  • Vol. 31, Iss. 16 — Aug. 15, 2006
  • pp: 2453–2455

In vivo three-dimensional photoacoustic tomography of a whole mouse head

Kwang Hyun Song, George Stoica, and Lihong V. Wang  »View Author Affiliations

Optics Letters, Vol. 31, Issue 16, pp. 2453-2455 (2006)

View Full Text Article

Enhanced HTML    Acrobat PDF (445 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



An in vivo photoacoustic imaging system was designed and implemented to image the entire small animal head. A special scanning gantry was designed to enable in vivo imaging in coronal cross sections with high contrast and good spatial resolution for the first time to our knowledge. By use of a 2.25 MHz ultrasonic transducer with a 6 mm diameter active element, an in-plane radial resolution of 312 μ m was achieved. Deeply seated arterial and venous vessels in the head measuring up to 1.7 cm in diameter were simultaneously imaged in vivo with 804 nm wavelength laser excitation of photoacoustic waves.

© 2006 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: April 4, 2006
Revised Manuscript: May 15, 2006
Manuscript Accepted: May 17, 2006
Published: July 25, 2006

Virtual Issues
Vol. 1, Iss. 9 Virtual Journal for Biomedical Optics

Kwang Hyun Song, George Stoica, and Lihong V. Wang, "In vivo three-dimensional photoacoustic tomography of a whole mouse head," Opt. Lett. 31, 2453-2455 (2006)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. S. L. Jacques and S. A. Prahl, 'Absorption spectra for biological tissues,' http://omlc.ogi.edu/.
  2. V. Ntziachristos, J. Ripoll, L.-H. Wang, and R. Weissleder, Nat. Biotechnol. 23, 313 (2005). [CrossRef] [PubMed]
  3. G. Ku and L.-H. Wang, Opt. Lett. 30, 507 (2005). [CrossRef] [PubMed]
  4. R. O. Esenaliev, A. A. Karabutov, and A. A. Oraevsky, IEEE J. Sel. Top. Quantum Electron. 5, 981 (1999). [CrossRef]
  5. G. Ku, X. Wang, G. Stoica, and L.-H. Wang, Phys. Med. Biol. 49, 1329 (2004). [CrossRef] [PubMed]
  6. X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L.-H. Wang, Nat. Biotechnol. 21, 803 (2003). [CrossRef] [PubMed]
  7. X. Wang, G. Ku, M. A. Wegiel, D. J. Bornhop, G. Stoica, and L.-H. Wang, Opt. Lett. 29, 730 (2004). [CrossRef] [PubMed]
  8. X. Wang and L.-H. Wang, Opt. Lett. 28, 1739 (2003). [CrossRef] [PubMed]
  9. R. A. Kruger, W. L. Kiser Jr., D. R. Reinecke, G. A. Kruger, and K. D. Miller, Mol. Imaging 2, 113 (2003). [CrossRef] [PubMed]
  10. American National Standards Institute, 'American national standard for the safe use of lasers,' ANSI Z136.1 (American National Standards Institute, 2000).
  11. K. Maslov, G. Stoica, and L.-H. Wang, Opt. Lett. 30, 625 (2005). [CrossRef] [PubMed]
  12. M. Xu and L.-H. Wang, Phys. Rev. E 67, 056605 (2003). [CrossRef]
  13. S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. C. van Gemert, Lasers Surg. Med. 12, 510 (1992). [CrossRef] [PubMed]
  14. L.-H. Wang, S. L. Jacques, and L. Zheng, Comput. Methods Programs Biomed. 47, 131 (1995). [CrossRef] [PubMed]
  15. J. F. Adam, H. Elleaume, G. L. Duc, S. Corde, A. M. Charvet, I. Troprès, J. F. L. Bas, and F. Estève, J. Cereb. Blood Flow Metab. 23, 499 (2003). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1 Fig. 2 Fig. 3

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited