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Optics Letters

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  • Editor: Anthony J. Campillo
  • Vol. 31, Iss. 23 — Dec. 1, 2006
  • pp: 3462–3464

Pulsed near-infrared laser diode excitation system for biomedical photoacoustic imaging

Thomas J. Allen and Paul C. Beard  »View Author Affiliations


Optics Letters, Vol. 31, Issue 23, pp. 3462-3464 (2006)
http://dx.doi.org/10.1364/OL.31.003462


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Abstract

A pulsed laser diode system operating at 905 nm has been developed for the generation of photoacoustic signals in tissue. It was evaluated by measuring the photoacoustic waveforms generated in a blood vessel phantom comprising three dye-filled ( μ a = 1 mm 1 ) tubes of diameters 120 580 μ m immersed to a maximum depth of 9 mm in a turbid liquid ( μ s = 1 mm 1 ) . The system was then combined with a cylindrical scanning system to obtain two-dimensional images of a tissue phantom. The signal-to-noise ratio of the detected signals in both cases and the image contrast in the latter suggest that such a system could provide a compact and inexpensive alternative to current excitation sources for superficial imaging applilcations.

© 2006 Optical Society of America

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(300.6430) Spectroscopy : Spectroscopy, photothermal

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: July 31, 2006
Manuscript Accepted: August 24, 2006
Published: November 9, 2006

Virtual Issues
Vol. 2, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Thomas J. Allen and Paul C. Beard, "Pulsed near-infrared laser diode excitation system for biomedical photoacoustic imaging," Opt. Lett. 31, 3462-3464 (2006)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-31-23-3462


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References

  1. M. Xu and L. V. Wang, Rev. Sci. Instrum. 77, 041101 (2006). [CrossRef]
  2. J. Laufer, C. E. Elwell, D. T. Delpy, and P. C. Beard, Phys. Med. Biol. 50, 4409 (2005). [CrossRef] [PubMed]
  3. Z. Zhao and R. Myllyla, Meas. Sci. Technol. 12, 2172 (2001). [CrossRef]
  4. R. G. M. Kolkman, W. Steenbergen, and T. G. van Leeuwen, Lasers Med. Sci. 21, 134 (2006). [CrossRef] [PubMed]
  5. T. J. Allen, B. T. Cox, P. C. Beard, in Proc. SPIE 5696, 233 (2005). [CrossRef]
  6. M. Xu and L. V. Wang, IEEE Trans. Biomed. Eng. 50, 1086 (2003). [CrossRef] [PubMed]

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