Diffraction phase microscopy for quantifying cell structure and dynamics
Optics Letters, Vol. 31, Issue 6, pp. 775-777 (2006)
http://dx.doi.org/10.1364/OL.31.000775
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Abstract
We have developed diffraction phase microscopy as a new technique for quantitative phase imaging of biological structures. The method combines the principles of common path interferometry and single-shot phase imaging and is characterized by subnanometer path-length stability and millisecond-scale acquisition time. The potential of the technique for quantifying nanoscale motions in live cells is demonstrated by experiments on red blood cells.
© 2006 Optical Society of America
OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.1530) Medical optics and biotechnology : Cell analysis
(180.0180) Microscopy : Microscopy
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: September 23, 2005
Revised Manuscript: November 12, 2005
Manuscript Accepted: December 5, 2005
Virtual Issues
Vol. 1, Iss. 4 Virtual Journal for Biomedical Optics
Citation
Gabriel Popescu, Takahiro Ikeda, Ramachandra R. Dasari, and Michael S. Feld, "Diffraction phase microscopy for quantifying cell structure and dynamics," Opt. Lett. 31, 775-777 (2006)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-31-6-775
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