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Optics Letters

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  • Editor: Anthony J. Campillo
  • Vol. 31, Iss. 7 — Apr. 1, 2006
  • pp: 924–926

Oxyhemoglobin saturation measurements by green spectral shift

Kurt R. Denninghoff, Russell A. Chipman, and Lloyd W. Hillman  »View Author Affiliations


Optics Letters, Vol. 31, Issue 7, pp. 924-926 (2006)
http://dx.doi.org/10.1364/OL.31.000924


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Abstract

From an analysis of new hemoglobin solution transmission spectra at various oxygen saturations ( S O 2 ) , path lengths, and pH, we find the determination of S O 2 by using the classical oximetry technique to be poorly calibrated. We used this data set to develop a proposed method for S O 2 determination based on the spectral shift of the hemoglobin transmission minimum between 475 and 510 nm. The method does not require accurate knowledge of hemoglobin extinction coefficients and is linear in relation to S O 2 despite changes in path length, pH, or hemoglobin concentration.

© 2006 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 17, 2005
Revised Manuscript: December 15, 2005
Manuscript Accepted: December 19, 2005

Virtual Issues
Vol. 1, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Kurt R. Denninghoff, Russell A. Chipman, and Lloyd W. Hillman, "Oxyhemoglobin saturation measurements by green spectral shift," Opt. Lett. 31, 924-926 (2006)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-31-7-924


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