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Optics Letters

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  • Editor: Anthony J. Campillo
  • Vol. 32, Iss. 11 — Jun. 1, 2007
  • pp: 1405–1407

Optoelectric biosensor using indium–tin–oxide electrodes

Chang Kyoung Choi, Kenneth D. Kihm, and Anthony E. English  »View Author Affiliations


Optics Letters, Vol. 32, Issue 11, pp. 1405-1407 (2007)
http://dx.doi.org/10.1364/OL.32.001405


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Abstract

The use of an optically thin indium–tin–oxide (ITO) electrode is presented for an optoelectric biosensor simultaneously recording optical images and microimpedance to examine time-dependent cellular growth. The transmittance of a 100 nm thick ITO electrode layer is approximately the same as the transmittance of a clean glass substrate, whereas the industry-standard Au ( 47.5 nm ) Ti ( 2.5 nm ) electrode layer drops the transmittance to less than 10% of that of the glass substrate. The simultaneous optoelectric measurements permit determining the correlation of the cell-covered area increase with the microimpedance increase, and the example results obtained for live porcine pulmonary artery endothelial cells delineate the quantitative and comprehensive nature of cellular attachment and spreading to the substrate, which has not been clearly perceived before.

© 2007 Optical Society of America

OCIS Codes
(170.1530) Medical optics and biotechnology : Cell analysis
(180.0180) Microscopy : Microscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 12, 2007
Manuscript Accepted: March 9, 2007
Published: April 26, 2007

Virtual Issues
Vol. 2, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Chang Kyoung Choi, Kenneth D. Kihm, and Anthony E. English, "Optoelectric biosensor using indium-tin-oxide electrodes," Opt. Lett. 32, 1405-1407 (2007)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-32-11-1405


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