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Optics Letters

Optics Letters


  • Editor: Anthony J. Campillo
  • Vol. 32, Iss. 22 — Nov. 15, 2007
  • pp: 3254–3256

Differential two-signal picosecond-pulse coherent anti-Stokes Raman scattering imaging microscopy by using a dual-mode optical parametric oscillator

Yong Shim Yoo, Dong-Hoon Lee, and Hyuck Cho  »View Author Affiliations

Optics Letters, Vol. 32, Issue 22, pp. 3254-3256 (2007)

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We propose and demonstrate a novel differential two-signal technique of coherent anti-Stokes Raman scattering (CARS) imaging microscopy using a picosecond (ps) optical parametric oscillator (OPO). By adjusting a Lyot filter inside the cavity, we operated the OPO oscillating in two stable modes separated by a few nanometers. The CARS images generated by the two modes are separated by a spectrograph behind the microscope setup, and their differential image is directly obtained by balanced lock-in detection. The feasibility of the technique is experimentally verified by imaging micrometer-sized polystyrene beads immersed in water.

© 2007 Optical Society of America

OCIS Codes
(170.6900) Medical optics and biotechnology : Three-dimensional microscopy
(180.0180) Microscopy : Microscopy
(190.4380) Nonlinear optics : Nonlinear optics, four-wave mixing
(300.6230) Spectroscopy : Spectroscopy, coherent anti-Stokes Raman scattering

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Original Manuscript: August 14, 2007
Revised Manuscript: September 29, 2007
Manuscript Accepted: October 9, 2007
Published: November 1, 2007

Virtual Issues
Vol. 2, Iss. 12 Virtual Journal for Biomedical Optics

Yong Shim Yoo, Dong-Hoon Lee, and Hyuck Cho, "Differential two-signal picosecond-pulse coherent anti-Stokes Raman scattering imaging microscopy by using a dual-mode optical parametric oscillator," Opt. Lett. 32, 3254-3256 (2007)

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  1. X. S. Xie, J. Yu, and W. Y. Yang, Science 312, 228 (2006). [CrossRef] [PubMed]
  2. L. Li, H. Wang, and J. X. Cheng, Biophys. J. 89, 3480 (2005). [CrossRef] [PubMed]
  3. F. Ganikhanov, C. L. Evans, B. G. Saar, and X. S. Xie, Opt. Lett. 31, 1872 (2006). [CrossRef] [PubMed]
  4. F. Ganikhanov, S. Carrasco, X. S. Xie, M. Katz, W. Steitz, and D. Kopf, Opt. Lett. 31, 1292 (2006). [CrossRef] [PubMed]
  5. Z. A. Yasa, A. Dienes, and J. R. Whinnery, Appl. Phys. Lett. 30, 24 (1977). [CrossRef]
  6. E. Bourkoff, J. R. Whinnery, and A. Dienes, Opt. Lett. 4, 179 (1979). [CrossRef] [PubMed]
  7. M. Jurna, J. P. Korterik, H. L. Offerhaus, and C. Otto, Appl. Phys. Lett. 89, 251116 (2006). [CrossRef]
  8. A. Volkmer, L. D. Book, and X. S. Xie, Appl. Phys. Lett. 80, 1505 (2002). [CrossRef]
  9. J.-X. Cheng, Y. K. Jia, G. Zheng, and X. S. Xie, Biophys. J. 83, 502 (2002). [CrossRef] [PubMed]

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