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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Anthony J. Campillo
  • Vol. 32, Iss. 22 — Nov. 15, 2007
  • pp: 3305–3307

Diagnostic cellular organization features extracted from autofluorescence images

Jonathan M. Levitt, Martin Hunter, Claudia Mujat, Margaret McLaughlin-Drubin, Karl Münger, and Irene Georgakoudi  »View Author Affiliations


Optics Letters, Vol. 32, Issue 22, pp. 3305-3307 (2007)
http://dx.doi.org/10.1364/OL.32.003305


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Abstract

Depth-resolved NADH autofluorescence images are shown to differentiate between normal and precancerous engineered tissues. An inverse power law behavior of the power spectral density (PSD) of these images is observed, indicating a self-affine organization of mitochondrial NADH at length scales 1– 10 μ m . Power exponents of the PSD functions vary significantly with tissue depth and precancerous state, giving insight into the morphological changes associated with precancerous lesions and providing substantial potential for noninvasive clinical diagnosis of squamous epithelial lesions and tumors.

© 2007 Optical Society of America

OCIS Codes
(070.5010) Fourier optics and signal processing : Pattern recognition
(170.1790) Medical optics and biotechnology : Confocal microscopy
(170.2520) Medical optics and biotechnology : Fluorescence microscopy
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: July 10, 2007
Revised Manuscript: October 9, 2007
Manuscript Accepted: October 10, 2007
Published: November 6, 2007

Virtual Issues
Vol. 2, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Jonathan M. Levitt, Martin Hunter, Claudia Mujat, Margaret McLaughlin-Drubin, Karl Münger, and Irene Georgakoudi, "Diagnostic cellular organization features extracted from autofluorescence images," Opt. Lett. 32, 3305-3307 (2007)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-32-22-3305


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