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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 33, Iss. 13 — Jul. 1, 2008
  • pp: 1530–1532

Speckle variance detection of microvasculature using swept-source optical coherence tomography

Adrian Mariampillai, Beau A. Standish, Eduardo H. Moriyama, Mamta Khurana, Nigel R. Munce, Michael K.K. Leung, James Jiang, Alex Cable, Brian C. Wilson, I. Alex Vitkin, and Victor X.D. Yang  »View Author Affiliations


Optics Letters, Vol. 33, Issue 13, pp. 1530-1532 (2008)
http://dx.doi.org/10.1364/OL.33.001530


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Abstract

We report on imaging of microcirculation by calculating the speckle variance of optical coherence tomography (OCT) structural images acquired using a Fourier domain mode-locked swept-wavelength laser. The algorithm calculates interframe speckle variance in two-dimensional and three-dimensional OCT data sets and shows little dependence to the Doppler angle ranging from 75° to 90°. We demonstrate in vivo detection of blood flow in vessels as small as 25 μ m in diameter in a dorsal skinfold window chamber model with direct comparison with intravital fluorescence confocal microscopy. This technique can visualize vessel-size-dependent vascular shutdown and transient vascular occlusion during Visudyne photodynamic therapy and may provide opportunities for studying therapeutic effects of antivascular treatments without on exogenous contrast agent.

© 2008 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Imaging Systems

History
Original Manuscript: April 7, 2008
Revised Manuscript: May 27, 2008
Manuscript Accepted: May 30, 2008
Published: June 30, 2008

Virtual Issues
Vol. 3, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Adrian Mariampillai, Beau A. Standish, Eduardo H. Moriyama, Mamta Khurana, Nigel R. Munce, Michael K. K. Leung, James Jiang, Alex Cable, Brian C. Wilson, I. Alex Vitkin, and Victor X. D. Yang, "Speckle variance detection of microvasculature using swept-source optical coherence tomography," Opt. Lett. 33, 1530-1532 (2008)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-33-13-1530


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References

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