Speckle variance detection of microvasculature using swept-source optical coherence tomography
Optics Letters, Vol. 33, Issue 13, pp. 1530-1532 (2008)
http://dx.doi.org/10.1364/OL.33.001530
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Abstract
We report on imaging of microcirculation by calculating the speckle variance of optical coherence tomography (OCT) structural images acquired using a Fourier domain mode-locked swept-wavelength laser. The algorithm calculates interframe speckle variance in two-dimensional and three-dimensional OCT data sets and shows little dependence to the Doppler angle ranging from 75° to 90°. We demonstrate in vivo detection of blood flow in vessels as small as
© 2008 Optical Society of America
OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging
ToC Category:
Imaging Systems
History
Original Manuscript: April 7, 2008
Revised Manuscript: May 27, 2008
Manuscript Accepted: May 30, 2008
Published: June 30, 2008
Virtual Issues
Vol. 3, Iss. 8 Virtual Journal for Biomedical Optics
Citation
Adrian Mariampillai, Beau A. Standish, Eduardo H. Moriyama, Mamta Khurana, Nigel R. Munce, Michael K. K. Leung, James Jiang, Alex Cable, Brian C. Wilson, I. Alex Vitkin, and Victor X. D. Yang, "Speckle variance detection of microvasculature using swept-source optical coherence tomography," Opt. Lett. 33, 1530-1532 (2008)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-33-13-1530
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