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Optics Letters

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  • Editor: Alan E. Willner
  • Vol. 33, Iss. 20 — Oct. 15, 2008
  • pp: 2290–2292

Analysis of the depth resolution limit of luminescence diffuse optical imaging

M. Boffety, M. Allain, A. Sentenac, M. Massonneau, and R. Carminati  »View Author Affiliations


Optics Letters, Vol. 33, Issue 20, pp. 2290-2292 (2008)
http://dx.doi.org/10.1364/OL.33.002290


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Abstract

We introduce a methodology to determine quantitatively the depth resolution limit in luminescence diffuse optical imaging. The approach is based on a Cramer–Rao statistical analysis, a noise model, and calculations of photon transport in tissues. We illustrate the method in the case of luminescence imaging in a brain–skull model, showing its potential applications in molecular imaging on small animals.

© 2008 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: July 1, 2008
Manuscript Accepted: August 11, 2008
Published: October 3, 2008

Virtual Issues
Vol. 3, Iss. 12 Virtual Journal for Biomedical Optics

Citation
M. Boffety, M. Allain, A. Sentenac, M. Massonneau, and R. Carminati, "Analysis of the depth resolution limit of luminescence diffuse optical imaging," Opt. Lett. 33, 2290-2292 (2008)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-33-20-2290


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