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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 33, Iss. 3 — Feb. 1, 2008
  • pp: 219–221

Self-phase modulation signatures of neuronal activity

Martin C. Fischer, Henry C. Liu, Ivan R. Piletic, Yasmin Escobedo-Lozoya, Ryohei Yasuda, and Warren S. Warren  »View Author Affiliations


Optics Letters, Vol. 33, Issue 3, pp. 219-221 (2008)
http://dx.doi.org/10.1364/OL.33.000219


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Abstract

We use phase-sensitive detection of spectral hole refilling to demonstrate strong novel intrinsic nonlinear signatures of neuronal activation in hippocampal brain slices. The ability to gain access to this fundamentally new intrinsic contrast with modest power levels suggests a new approach to in vivo neural imaging. We expect that we can extrapolate our method to high spatial and temporal resolution in deep tissue while retaining the noninvasive character.

© 2008 Optical Society of America

OCIS Codes
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7160) Medical optics and biotechnology : Ultrafast technology
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 21, 2007
Manuscript Accepted: December 13, 2007
Published: January 22, 2008

Virtual Issues
Vol. 3, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Martin C. Fischer, Henry C. Liu, Ivan R. Piletic, Yasmin Escobedo-Lozoya, Ryohei Yasuda, and Warren S. Warren, "Self-phase modulation signatures of neuronal activity," Opt. Lett. 33, 219-221 (2008)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-33-3-219


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