OSA's Digital Library

Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 34, Iss. 3 — Feb. 1, 2009
  • pp: 232–234

In vivo photosensitizer tomography inside the human prostate

Johan Axelsson, Johannes Swartling, and Stefan Andersson-Engels  »View Author Affiliations

Optics Letters, Vol. 34, Issue 3, pp. 232-234 (2009)

View Full Text Article

Enhanced HTML    Acrobat PDF (262 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



Interstitial photodynamic therapy (IPDT) provides a promising means to treat large cancerous tumors and solid organs inside the human body. The treatment outcome is dependent on the distributions of light, photosensitizer, and tissue oxygenation. We present a scheme for reconstructing the spatial distribution of a fluorescent photosensitizer. The reconstruction is based on measurements performed in the human prostate, acquired during an ongoing IPDT clinical trial, as well as in optical phantoms. We show that in an experimental setup we can quantitatively reconstruct a fluorescent inclusion in a fluorescent background. We also show reconstructions from a patient showing a heterogeneous distribution of the photosensitizer mTHPC in the human prostate.

© 2009 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(170.7230) Medical optics and biotechnology : Urology

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: October 7, 2008
Revised Manuscript: November 28, 2008
Manuscript Accepted: November 29, 2008
Published: January 21, 2009

Virtual Issues
Vol. 4, Iss. 4 Virtual Journal for Biomedical Optics

Johan Axelsson, Johannes Swartling, and Stefan Andersson-Engels, "In vivo photosensitizer tomography inside the human prostate," Opt. Lett. 34, 232-234 (2009)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. K. L. Du, R. Mick, T. Busch, T. C. Zhu, J. C. Finlay, G. Yu, A. G. Yodh, S. B. Malkowicz, D. Smith, R. Whittington, D. Stripp, and S. M. Hahn, Lasers Surg. Med. 38, 427 (2006). [CrossRef] [PubMed]
  2. C. M. Moore, T. R. Nathan, W. R. Lees, C. A. Mosse, A. Freeman, M. Emberton, and S. G. Bown, Lasers Surg. Med. 38, 356 (2006). [CrossRef] [PubMed]
  3. R. A. Weersink, A. Bogaards, M. Gertner, S. R. H. Davidson, K. Zhang, G. Netchev, J. Trachtenberg, and B. C. Wilson, J. Photochem. Photobiol. B 79, 211 (2005). [CrossRef] [PubMed]
  4. B. C. Wilson, M. S. Patterson, and L. Lilge, Lasers Med. Sci. 12, 182 (1997). [CrossRef] [PubMed]
  5. A. Johansson, J. Axelsson, S. Andersson-Engels, and J. Swartling, Med. Phys. 34, 4309 (2007). [CrossRef] [PubMed]
  6. M. D. Altschuler, T. C. Zhu, J. Li, and S. M. Hahn, Med. Phys. 32, 3524 (2005). [CrossRef]
  7. X. D. Zhou, B. W. Pogue, B. Chen, E. Demidenko, R. Joshi, J. Hoopes, and T. Hasan, Int. J. Radiat. Oncol. Biol. Phys. 64, 1211 (2006). [CrossRef] [PubMed]
  8. M. Soto-Thompson, A. Johansson, T. Johansson, S. Andersson-Engels, S. Svanberg, N. Bendsoe, and K. Svanberg, Appl. Opt. 44, 4023 (2005). [CrossRef]
  9. S. R. Arridge, Inverse Probl. 15, R41 (1999). [CrossRef]
  10. V. Ntziachristos and R. Weissleder, Opt. Lett. 26, 893 (2001). [CrossRef]
  11. P. K. Yalavarthy, B. W. Pogue, H. Dehghani, and K. D. Paulsen, Med. Phys. 34, 2085 (2007). [CrossRef] [PubMed]
  12. B. A. Brooksby, “Combining near infrared tomography and magnetic resonance imaging to improve breast tissue chromophore and scattering assessment,” Ph.D. dissertation (Dartmouth College, 2005).
  13. P. C. Hansen, Numer. Algorithms 6, 1 (1994). [CrossRef]
  14. E. Alerstam, S. Andersson-Engels, and T. Svensson, Opt. Express 16, 10440 (2008). [CrossRef] [PubMed]
  15. R. Sens and K. H. Drexhage, J. Lumin. 24, 709 (1981). [CrossRef]
  16. J. Axelsson, J. Svensson, and S. Andersson-Engels, Opt. Express 15, 13574 (2007). [CrossRef] [PubMed]
  17. J. C. Finlay, T. C. Zhu, A. Dimofte, D. Stripp, S. B. Malkowcz, T. M. Busch, and S. M. Hahn, Photochem. Photobiol. 82, 1270 (2006). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1 Fig. 2 Fig. 3

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited