Are quantitative attenuation measurements of blood by optical coherence tomography feasible?
Optics Letters, Vol. 34, Issue 9, pp. 1435-1437 (2009)
http://dx.doi.org/10.1364/OL.34.001435
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Abstract
We present optical coherence tomography (OCT) measurements on fully physiologically oxygenated blood samples of varying hematocrit. We show that attenuation coefficients cannot be extracted quantitatively using the currently accepted models for the OCT signal from scattering media, because the confidence intervals obtained in the fitting procedure cannot be used as reliable uncertainty estimates of the attenuation coefficients. Better modeling of the hematocrit-dependent OCT signal is needed.
© 2009 Optical Society of America
OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.4500) Medical optics and biotechnology : Optical coherence tomography
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: December 24, 2008
Revised Manuscript: March 24, 2009
Manuscript Accepted: April 2, 2009
Published: April 28, 2009
Virtual Issues
Vol. 4, Iss. 7 Virtual Journal for Biomedical Optics
Citation
Dirk J. Faber and Ton G. van Leeuwen, "Are quantitative attenuation measurements of blood by optical coherence tomography feasible?," Opt. Lett. 34, 1435-1437 (2009)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-34-9-1435
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