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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 34, Iss. 9 — May. 1, 2009
  • pp: 1480–1482

Simultaneous imaging of cortical hemodynamics and blood oxygenation change during cerebral ischemia using dual-wavelength laser speckle contrast imaging

Zhongchi Luo, Zhijia Yuan, Yingtian Pan, and Congwu Du  »View Author Affiliations

Optics Letters, Vol. 34, Issue 9, pp. 1480-1482 (2009)

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A dual-wavelength laser speckle contrast imaging technique (DW-LSCI) is presented for simultaneous imaging of cerebral blood flow and hemoglobin oxygenation changes at high spatiotemporal resolutions. Experimental validation was performed using a rat transient forebrain ischemia model. The results showed that DW-LSCI was able to track detailed hemodynamic and metabolic changes induced by ischemia, i.e., decreased oxy- and total hemoglobin concentrations and blood flow as well as increased deoxy-hemoglobin concentration in the downstream regions, thus allowing us to distinguish cerebral arterial and venous flows. Simultaneous cerebral blood flow and oxygenation imaging at high spatiotemporal resolutions is crucial to the understanding of neural process and brain functions.

© 2009 Optical Society of America

OCIS Codes
(110.6150) Imaging systems : Speckle imaging
(170.0110) Medical optics and biotechnology : Imaging systems
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: December 18, 2008
Revised Manuscript: March 21, 2009
Manuscript Accepted: March 24, 2009
Published: April 30, 2009

Virtual Issues
Vol. 4, Iss. 7 Virtual Journal for Biomedical Optics

Zhongchi Luo, Zhijia Yuan, Yingtian Pan, and Congwu Du, "Simultaneous imaging of cortical hemodynamics and blood oxygenation change during cerebral ischemia using dual-wavelength laser speckle contrast imaging," Opt. Lett. 34, 1480-1482 (2009)

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