Abstract
Present techniques for prenatal diagnosis are invasive and present significant risks of fetal loss. Noninvasive prenatal diagnosis utilizing fetal nucleated red blood cells (fNRBC) circulating in maternal peripheral blood has received attention, since it poses no risk to the fetus. However, because of the failure to find broadly applicable identifiers that can differentiate fetal from adult NRBC, reliable detection of viable fNRBC in amounts sufficient for clinical use remains a challenge. In this Letter we show that fNRBC light-scattering spectroscopic signatures may lead to a clinically useful method of minimally invasive prenatal genetic testing.
© 2009 Optical Society of America
Full Article | PDF ArticleMore Like This
Xiaozhou Li, Tianyue Yang, Caesar Siqi Li, Lili Jin, Hong Lou, and Youtao Song
Biomed. Opt. Express 9(7) 3167-3176 (2018)
P. M. A. Sloot and C. G. Figdor
Appl. Opt. 25(19) 3559-3565 (1986)
Matti Kinnunen, Antti Kauppila, Artashes Karmenyan, and Risto Myllylä
Opt. Lett. 36(18) 3554-3556 (2011)