OSA's Digital Library

Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 35, Iss. 13 — Jul. 1, 2010
  • pp: 2121–2123

Time-resolved diffuse optical tomography with patterned-light illumination and detection

Jin Chen, Vivek Venugopal, Frederic Lesage, and Xavier Intes  »View Author Affiliations

Optics Letters, Vol. 35, Issue 13, pp. 2121-2123 (2010)

View Full Text Article

Enhanced HTML    Acrobat PDF (405 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



This investigation explores the feasibility of performing diffuse optical tomography based on time-domain wide-field illumination and detection strategies. Wide-field patterned excitation and detection schemes are investigated in transmittance geometry with time-gated detection channels. A Monte Carlo forward model is employed to compute the time-resolved Jacobians for rigorous light propagation modeling. We demonstrate both in silico and experimentally that reconstructions of absorption structures based on wide-field patterned-light strategies are feasible and outperform classical point excitation schemes for similar data set sizes. Moreover, we demonstrate that time-domain information is retained even though large spatial areas are illuminated. The enhanced time-domain data set allows for quantitative three-dimensional imaging in thick tissue based on relatively small data sets associated with much shorter acquisition times.

© 2010 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 5, 2010
Revised Manuscript: May 6, 2010
Manuscript Accepted: May 9, 2010
Published: June 21, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics

Jin Chen, Vivek Venugopal, Frederic Lesage, and Xavier Intes, "Time-resolved diffuse optical tomography with patterned-light illumination and detection," Opt. Lett. 35, 2121-2123 (2010)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. X. Intes, S. Djeziri, Z. Ichalalene, N. Mincu, Y. Wang, P. St-Jean , F. Lesage, D. Hall, D. Boas, M. Polyzos, D. Fleiszer, and B. Mesurolle, Acad. Radiol. 12, 934 (2005). [CrossRef] [PubMed]
  2. B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, Med. Phys. 35, 2443 (2008). [CrossRef] [PubMed]
  3. G. Strangman, D. A. Boas, and J. P. Sutton, Biol. Psychiatry 52, 679 (2002). [CrossRef] [PubMed]
  4. X. Intes and B. Chance, Radiol. Clin. N. Am. 43, 221 (2005). [CrossRef] [PubMed]
  5. D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, J Biomed. Opt. 14, 024012 (2009). [CrossRef] [PubMed]
  6. V. Lukic, V. Markel, and J. C. Shcotland, Opt. Lett. 34, 983 (2009) [CrossRef] [PubMed]
  7. A. Bassi, C. D’Andrea, G. Valentini, R. Cubeddu, and S. Arridge, Opt. Lett. 34, 2156 (2009). [CrossRef] [PubMed]
  8. S. Belanger, M. Abran, X. Intes, C. Casanova, and F. Lesage, J Biomed. Opt. 15, 016006 (2010). [CrossRef] [PubMed]
  9. J. Chen and X. Intes, Opt. Express 17, 19566 (2009). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1 Fig. 2 Fig. 3
Fig. 4

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited