An analysis of the photoacoustic (PA) signal from murine tissue in vivo revealed several benefits of contrast- enhanced PA imaging at a wavelength of $1064\mathrm{nm}$ . Of all the wavelengths tested in a range from 710 to $1064\mathrm{nm}$ , the background PA signal from tissue in vivo was lowest and more homogeneous at $1064\mathrm{nm}$ . For blood-laden tissue, the background PA signal was up to 70% less at $1064\mathrm{nm}$ . Furthermore, when plasmonic nanoparticles, such as silver nanoplates, were introduced in vivo as contrast agents, the contrast in PA images at $1064\mathrm{nm}$ increased 38% compared to $750\mathrm{nm}$ . Therefore, contrast-enhanced PA imaging at $1064\mathrm{nm}$ is advantageous because of the low and homogeneous signal from native tissue, enabling high contrast in PA imaging when exogenous, molecularly targeted agents are employed.

© 2010 Optical Society of America

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