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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 35, Iss. 20 — Oct. 15, 2010
  • pp: 3345–3347

Tomographic molecular imaging of x-ray-excitable nanoparticles

Guillem Pratx, Colin M. Carpenter, Conroy Sun, Ravi P. Rao, and Lei Xing  »View Author Affiliations

Optics Letters, Vol. 35, Issue 20, pp. 3345-3347 (2010)

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X-ray luminescence computed tomography (XLCT) is proposed as a new dual molecular/anatomical imaging modality. XLCT is based on the selective excitation and optical detection of x-ray-excitable nanoparticles. As a proof of concept, we built a prototype XLCT system and imaged near-IR-emitting Gd 2 O 2 S : Eu phosphors in various phantoms. Imaging in an optically diffusive medium shows that imaging performance is not affected by optical scatter; furthermore, the linear response of the reconstructed images suggests that XLCT is capable of quantitative imaging.

© 2010 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6960) Medical optics and biotechnology : Tomography
(170.7440) Medical optics and biotechnology : X-ray imaging
(250.1500) Optoelectronics : Cathodoluminescence

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: May 19, 2010
Revised Manuscript: August 9, 2010
Manuscript Accepted: August 18, 2010
Published: October 8, 2010

Guillem Pratx, Colin M. Carpenter, Conroy Sun, Ravi P. Rao, and Lei Xing, "Tomographic molecular imaging of x-ray-excitable nanoparticles," Opt. Lett. 35, 3345-3347 (2010)

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