OSA's Digital Library

Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 35, Iss. 20 — Oct. 15, 2010
  • pp: 3501–3503

Plasmonics-based spatially activated light microscopy for super-resolution imaging of molecular fluorescence

Kyujung Kim, Youngjin Oh, Wonju Lee, and Donghyun Kim  »View Author Affiliations


Optics Letters, Vol. 35, Issue 20, pp. 3501-3503 (2010)
http://dx.doi.org/10.1364/OL.35.003501


View Full Text Article

Enhanced HTML    Acrobat PDF (332 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

In this Letter, we explore plasmonics-based spatially activated light microscopy (PSALM) for sub-diffraction-limited imaging of biomolecules. PSALM is based on the spatially switched activation of local amplified electromagnetic hot spots under multiple light incidence conditions. The hot spots are associated with surface plasmons that are excited and localized by surface nanostructures. The feasibility of the concept was demonstrated by imaging fluorescent nanobeads on a two-dimensional gold nanograting of a 100-nm-wide grating ridge, the size of which is the measure of the imaging resolution. The result confirms the performance of PSALM for imaging nanobeads at a resolution below the conventional diffraction limit.

© 2010 Optical Society of America

OCIS Codes
(100.6640) Image processing : Superresolution
(180.2520) Microscopy : Fluorescence microscopy
(240.6680) Optics at surfaces : Surface plasmons
(310.6628) Thin films : Subwavelength structures, nanostructures

ToC Category:
Microscopy

History
Original Manuscript: June 22, 2010
Revised Manuscript: August 8, 2010
Manuscript Accepted: August 31, 2010
Published: October 14, 2010

Citation
Kyujung Kim, Youngjin Oh, Wonju Lee, and Donghyun Kim, "Plasmonics-based spatially activated light microscopy for super-resolution imaging of molecular fluorescence," Opt. Lett. 35, 3501-3503 (2010)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-35-20-3501


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. S. W. Hell, Science 316, 1153 (2007). [CrossRef] [PubMed]
  2. M. G. L. Gustafsson, Proc. Natl. Acad. Sci. USA 102, 13081(2005). [CrossRef] [PubMed]
  3. E. Betzig, G. H. Patterson, R. Sougrat, O. W. Lindwasser, S. Olenych, J. S. Bonifacino, M. W. Davidson, J. Lippincott-Schwartz, and H. F. Hess, Science 313, 1642 (2006). [CrossRef] [PubMed]
  4. T. J. Gould, V. V. Verkhusha, and S. T. Hess, Nat. Protocols 4, 291 (2009). [CrossRef]
  5. M. J. Rust, M. Bates, and X. Zhuang, Nat. Methods 3, 793(2006). [CrossRef] [PubMed]
  6. H. Yokota, K. Saito, and T. Yanagida, Phys. Rev. Lett. 80, 4606 (1998). [CrossRef]
  7. T. Liebermann and W. Knoll, Colloids Surf. A 171, 115(2000). [CrossRef]
  8. F. Yu, B. Persson, S. Löfås, and W. Knoll, J. Am. Chem. Soc. 126, 8902 (2004). [CrossRef] [PubMed]
  9. K. Tawa and K. Morigaki, Biophys. J. 89, 2750 (2005). [CrossRef] [PubMed]
  10. E. Fort and S. Grésillon, J. Phys. D 41, 013001 (2008). [CrossRef]
  11. D. P. Fromm, A. Sundaramurthy, P. J. Schuck, G. Kino, and W. E. Moerner, Nano Lett. 4, 957 (2004). [CrossRef]
  12. P. Andrew and W. L. Barnes, Phys. Rev. B 64, 125405(2001). [CrossRef]
  13. K. Kim, D. J. Kim, E.-J. Cho, J.-S. Suh, Y.-M. Huh, and D. Kim, Nanotechnol. 20, 015202 (2009). [CrossRef]
  14. K. Kim, J.-W. Choi, K. Ma, R. Lee, K.-H. Yoo, C.-O. Yun, and D. Kim, Small 6, 1293 (2010). [CrossRef] [PubMed]
  15. K. Kim, Y. Oh, K. Ma, E. Sim, and D. Kim, Opt. Lett. 34, 3905 (2009). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1 Fig. 2 Fig. 3
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited