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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 35, Iss. 22 — Nov. 15, 2010
  • pp: 3739–3741

Analysis of a diffusion-model-based approach for efficient quantification of superficial tissue properties

Sheng-Hao Tseng and Ming-Feng Hou  »View Author Affiliations

Optics Letters, Vol. 35, Issue 22, pp. 3739-3741 (2010)

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Previously, we reported using a diffusing probe in conjunction with a two-layer diffusion model for accurately recovering the optical properties of superficial volumes. However, the two-layer diffusion equation is computationally less efficient than a standard diffusion equation (SDE) by 3 orders of magnitude. In this Letter, we present a new approach extended from the diffusing probe geometry that enables the use of a diffusion model that has efficiency comparable to an SDE. Our Monte Carlo simulation results indicate that this new approach is not only very accurate but also sensitive to the presence of 0.5 mm 3 inhomogeneities and could be used for monitoring the early progression of skin melanoma.

© 2010 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5270) Medical optics and biotechnology : Photon density waves
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: September 9, 2010
Manuscript Accepted: October 1, 2010
Published: November 3, 2010

Virtual Issues
Vol. 6, Iss. 1 Virtual Journal for Biomedical Optics

Sheng-Hao Tseng and Ming-Feng Hou, "Analysis of a diffusion-model-based approach for efficient quantification of superficial tissue properties," Opt. Lett. 35, 3739-3741 (2010)

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