On the potential for molecular imaging with Cerenkov luminescence
Optics Letters, Vol. 35, Issue 23, pp. 3889-3891 (2010)
http://dx.doi.org/10.1364/OL.35.003889
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Abstract
Recent observation of optical luminescence due to beta decay from suitable radiotracers has led to the possible development of new preclinical optical imaging methods. The generation of photons that can be detected using instrumentation optimized for bioluminescence imaging has been putatively associated with the Cerenkov effect. We describe the simultaneous utilization of fluorescence reporters to convert Cerenkov luminescence to longer wavelengths for better tissue penetration and also for modulating the luminescence spectrum for potential molecular imaging strategies.
© 2010 Optical Society of America
OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(260.3800) Physical optics : Luminescence
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: September 1, 2010
Revised Manuscript: October 25, 2010
Manuscript Accepted: October 27, 2010
Published: November 18, 2010
Citation
Matthew A. Lewis, Vikram D. Kodibagkar, Orhan K. Öz, and Ralph P. Mason, "On the potential for molecular imaging with Cerenkov luminescence," Opt. Lett. 35, 3889-3891 (2010)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-35-23-3889
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