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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 35, Iss. 23 — Dec. 1, 2010
  • pp: 3964–3966

Rapid magnetic resonance-guided near-infrared mapping to image pulsatile hemoglobin in the breast

Zhiqiu Li, Venkataramanan Krishnaswamy, Shudong Jiang, Scott C. Davis, Subhadra Srinivasan, Keith D. Paulsen, and Brian W. Pogue  »View Author Affiliations

Optics Letters, Vol. 35, Issue 23, pp. 3964-3966 (2010)

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A near-IR (NIR) tomography system with spectral-encoded sources was built to quantify the temporal contrast in human breast tissue using guidance from magnetic resonance imaging. The systems were integrated with a custom breast coil interface to provide simultaneous acquisition. The NIR signal was synchronized to simultaneous finger pulse oximeter plethysmogram, which offered a frequency reference. A 0.1 s temporal delay of the absorption pulse within adipose tissue relative to fibroglandular tissue was found, in an initial human study, showing the potential for novel contrast imaging of fast flow signals in deep tissue.

© 2010 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6960) Medical optics and biotechnology : Tomography
(170.7160) Medical optics and biotechnology : Ultrafast technology

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: September 3, 2010
Revised Manuscript: October 1, 2010
Manuscript Accepted: October 27, 2010
Published: November 23, 2010

Zhiqiu Li, Venkataramanan Krishnaswamy, Shudong Jiang, Scott C. Davis, Subhadra Srinivasan, Keith D. Paulsen, and Brian W. Pogue, "Rapid magnetic resonance-guided near-infrared mapping to image pulsatile hemoglobin in the breast," Opt. Lett. 35, 3964-3966 (2010)

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  1. Z. Li, V. Krishnaswamy, S. C. Davis, S. Srinivasan, K. D. Paulsen, and B. W. Pogue, Opt. Express 17, 12043 (2009). [CrossRef] [PubMed]
  2. D. Piao, H. Dehghani, S. Jiang, S. Srinivasan, and B. Pogue, Rev. Sci. Instrum. 76, 124301 (2005). [CrossRef]
  3. R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, Med. Phys. 32, 1128 (2005). [CrossRef] [PubMed]
  4. S. Jiang, B. W. Pogue, C. M. Carpenter, S. P. Poplack, W. A. Wells, C. A. Kogel, J. A. Forero, L. S. Muffly, G. N. Schwartz, K. D. Paulsen, and P. A. Kaufman, Radiology 252, 551(2009). [CrossRef] [PubMed]
  5. A. E. Cerussi, V. W. Tanamai, R. S. Mehta, D. Hsiang, J. Butler, and B. J. Tromberg, Acad. Radiol. 17, 1031 (2010). [CrossRef] [PubMed]
  6. H. Soliman, A. Gunasekara, M. Rycroft, J. Zubovits, R. Dent, J. Spayne, M. J. Yaffe, and G. J. Czarnota, Clin. Cancer Res. 16, 2605 (2010). [CrossRef] [PubMed]
  7. B. J. Tromberg and A. E. Cerussi, Clin. Cancer Res. 16, 2486 (2010). [CrossRef] [PubMed]
  8. B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, Proc. Natl. Acad. Sci. USA 103, 8828 (2006). [CrossRef] [PubMed]
  9. H. Dehghani, M. Eames, P. Yalavarthy, S. Davis, S. Srinivasan, C. Carpenter, B. Pogue, and K. Paulsen, Commun. Numer. Methods Eng. 25, 711 (2009). [CrossRef]
  10. B. Brooksby, H. Dehghani, B. Pogue, and K. Paulsen, IEEE J. Sel. Top. Quantum Electron. 9, 199 (2003). [CrossRef]
  11. M. Reinhard, E. Wehrle-Wieland, D. Grabiak, M. Roth, B. Guschlbauer, J. Timmer, C. Weiller, and A. Hetzel, J. Neurol. Sci. 250, 103 (2006). [CrossRef] [PubMed]
  12. H. Obrig, M. Neufang, R. Wenzel, M. Kohl, J. Steinbrink, K. Einhaupl, and A. Villringer, NeuroImage 12, 623 (2000). [CrossRef] [PubMed]

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