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Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 35, Iss. 5 — Mar. 1, 2010
  • pp: 700–702

Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells

Chao Zhou, Tsung-Han Tsai, Desmond C. Adler, Hsiang-Chieh Lee, David W. Cohen, Amy Mondelblatt, Yihong Wang, James L. Connolly, and James G. Fujimoto  »View Author Affiliations


Optics Letters, Vol. 35, Issue 5, pp. 700-702 (2010)
http://dx.doi.org/10.1364/OL.35.000700


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Abstract

We demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300-600 μm deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells.

© 2010 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.4730) Medical optics and biotechnology : Optical pathology
(170.6930) Medical optics and biotechnology : Tissue
(190.4870) Nonlinear optics : Photothermal effects
(160.4236) Materials : Nanomaterials

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 9, 2009
Manuscript Accepted: December 14, 2009
Published: February 25, 2010

Virtual Issues
Vol. 5, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Chao Zhou, Tsung-Han Tsai, Desmond C. Adler, Hsiang-Chieh Lee, David W. Cohen, Amy Mondelblatt, Yihong Wang, James L. Connolly, and James G. Fujimoto, "Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells," Opt. Lett. 35, 700-702 (2010)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-35-5-700

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