This Letter reports on the use of a supercontinuum light source to achieve ultrahigh resolution and ultrahigh sensitive optical microangiography (OMAG) imaging of microcirculations within tissue beds in vivo. After passing through a specially designed optical filter with a passband of $120\mathrm{nm}$ centered on $800\mathrm{nm}$ , the light source is coupled into an optic-fiber-based OMAG system that provides a measured axial resolution of $\sim 3\mathrm{\mu m}$ over a ranging distance of $2\mathrm{mm}$ . Within this ranging distance, the system gives an averaged signal-to-noise ratio of $87\mathrm{dB}$ and a sensitivity roll-off of $7\mathrm{dB}$ at an A-scan rate of $70\mathrm{kHz}$ . We demonstrate the capability of the system to visualize a detailed microvascular perfusion map, including the single red blood cells within the capillaries, by imaging a mouse ear flap in vivo.

© 2011 Optical Society of America

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