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Viscoelasticity imaging of biological tissues with phase-resolved photoacoustic measurement |
Optics Letters, Vol. 36, Issue 17, pp. 3341-3343 (2011)
http://dx.doi.org/10.1364/OL.36.003341
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Abstract
A method for noninvasive viscoelasticity imaging of biological tissues using phase-resolved photoacoustic measurement is presented. We deduced the process of photoacoustic effect on the basis of thermal viscoelasticity theory, and established the relationship between the photoacoustic phase delay and the viscosity–elasticity ratio for soft solids. Agar phantoms with different densities and different absorption coefficients were used to verify the dependence of photoacoustic phase-resolved viscoelasticity measurements. Moreover, viscoelasticity imaging of tissues was obtained with a photoacoustic point scanning system. The photoacoustic phase-resolved method provides a basis for viscoelasticity imaging, which can potentially be used for detection of viscoelastic properties and lesions of biological tissues.
© 2011 Optical Society of America
OCIS Codes
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.6935) Medical optics and biotechnology : Tissue characterization
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: May 25, 2011
Revised Manuscript: July 26, 2011
Manuscript Accepted: July 27, 2011
Published: August 19, 2011
Virtual Issues
Vol. 6, Iss. 10 Virtual Journal for Biomedical Optics
Citation
Guodong Gao, Sihua Yang, and Da Xing, "Viscoelasticity imaging of biological tissues with phase-resolved photoacoustic measurement," Opt. Lett. 36, 3341-3343 (2011)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-36-17-3341
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