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  • Vol. 36, Iss. 20 — Oct. 15, 2011
  • pp: 4086–4088

In vivo photoacoustic time-of-flight velocity measurement of single cells and nanoparticles

M. Sarimollaoglu, D. A. Nedosekin, Y. Simanovsky, E. I. Galanzha, and V. P. Zharov  »View Author Affiliations


Optics Letters, Vol. 36, Issue 20, pp. 4086-4088 (2011)
http://dx.doi.org/10.1364/OL.36.004086


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Abstract

Optical techniques for in vivo measurement of blood flow velocity are not quite applicable for determination of velocity of individual cells or nanoparticles. Here, we describe a photoacoustic time-of-flight method to measure the velocity of individual absorbing objects by using single and multiple laser beams. Its capability was demonstrated in vitro on blood vessel phantom and in vivo on an animal (mouse) model for estimating velocity of gold nanorods, melanin nanoparticles, erythrocytes, leukocytes, and circulating tumor cells in the broad range of flow velocity from 0.1 mm / s to 14 cm / s . Object velocity can be used to identify single cells circulating at different velocities or cell aggregates and to determine a cell’s location in a vessel cross-section.

© 2011 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.1530) Medical optics and biotechnology : Cell analysis
(350.4990) Other areas of optics : Particles

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: May 27, 2011
Revised Manuscript: August 19, 2011
Manuscript Accepted: September 10, 2011
Published: October 13, 2011

Virtual Issues
Vol. 6, Iss. 11 Virtual Journal for Biomedical Optics

Citation
M. Sarimollaoglu, D. A. Nedosekin, Y. Simanovsky, E. I. Galanzha, and V. P. Zharov, "In vivo photoacoustic time-of-flight velocity measurement of single cells and nanoparticles," Opt. Lett. 36, 4086-4088 (2011)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-36-20-4086


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References

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