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Model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parameters |
Optics Letters, Vol. 37, Issue 13, pp. 2571-2573 (2012)
http://dx.doi.org/10.1364/OL.37.002571
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Abstract
Optical dye-dilution techniques can quantify kinetic parameters in a region of tissue, but currently rely on a two-step process—spatial reconstruction of the dye concentration, repeated at every time-point, and subsequent kinetic analysis of the time-dependent change in dye concentration. Inaccuracies, in this approach, are due mainly to the ill-posed nature of the spatial reconstruction problem, which propagates into kinetic analysis and result in errors in extracted dynamic parameters. We present a hybrid kinetic deconvolution optical reconstruction algorithm, effectively combining optical reconstruction and model-independent kinetic analysis into a single inverse problem that is better posed. Kinetic parameters of multiple tissue regions can be quantified simultaneously. As proof of principle, we provide numerical experiments in reflectance-based and fluorescence molecular tomography scenarios.
© 2012 Optical Society of America
OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6960) Medical optics and biotechnology : Tomography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: March 7, 2012
Revised Manuscript: April 16, 2012
Manuscript Accepted: May 15, 2012
Published: June 22, 2012
Virtual Issues
Vol. 7, Iss. 9 Virtual Journal for Biomedical Optics
Citation
Jonathan T. Elliott, Mamadou Diop, Ting-Yim Lee, and Keith St. Lawrence, "Model-independent dynamic constraint to improve the optical reconstruction of regional kinetic parameters," Opt. Lett. 37, 2571-2573 (2012)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-37-13-2571
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