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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 37, Iss. 18 — Sep. 15, 2012
  • pp: 3867–3869

Polarization-extinction-based detection of DNA hybridization in situ using a nanoparticle wire-grid polarizer

Hojeong Yu, Youngjin Oh, Soowon Kim, Seok Ho Song, and Donghyun Kim  »View Author Affiliations

Optics Letters, Vol. 37, Issue 18, pp. 3867-3869 (2012)

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Metallic wires can discriminate light polarization due to strong absorption of electric fields oscillating in parallel to wires. Here, we explore polarization-based biosensing of DNA hybridization in situ by employing metal target-conjugated nanoparticles to form a wire-grid polarizer (WGP) as complementary DNA strands hybridize. Experimental results using gold nanoparticles of 15 nm diameter to form a WGP of 400 nm period suggest that polarization extinction can detect DNA hybridization with a limit of detection in the range of 1 nM concentration. The sensitivity may be improved by more than an order of magnitude if larger nanoparticles are employed to define WGPs at a period between 400 and 500 nm.

© 2012 Optical Society of America

OCIS Codes
(120.1880) Instrumentation, measurement, and metrology : Detection
(230.5440) Optical devices : Polarization-selective devices
(280.1415) Remote sensing and sensors : Biological sensing and sensors

ToC Category:
Optical Devices

Original Manuscript: July 10, 2012
Revised Manuscript: July 31, 2012
Manuscript Accepted: July 31, 2012
Published: September 14, 2012

Virtual Issues
Vol. 7, Iss. 11 Virtual Journal for Biomedical Optics

Hojeong Yu, Youngjin Oh, Soowon Kim, Seok Ho Song, and Donghyun Kim, "Polarization-extinction-based detection of DNA hybridization in situusing a nanoparticle wire-grid polarizer," Opt. Lett. 37, 3867-3869 (2012)

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