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Noncontact measurement of elasticity for the detection of soft-tissue tumors using phase-sensitive optical coherence tomography combined with a focused air-puff system |
Optics Letters, Vol. 37, Issue 24, pp. 5184-5186 (2012)
http://dx.doi.org/10.1364/OL.37.005184
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Abstract
We report on an optical noncontact method for the detection of soft-tissue tumors based on the measurement of their elasticity. A focused air-puff system is used to excite surface waves (SWs) on soft tissues with transient static pressure. A high-speed phase-sensitive optical coherence tomography system is used to measure the SWs as they propagate from the point of excitation. To evaluate the stiffness of soft tissues, the Young’s modulus is quantified based on the group velocity of SWs. Pilot experiments were performed on ex vivo human myxoma and normal fat. Results demonstrate the feasibility of the proposed method to measure elasticity and differentiate soft-tissue tumors from normal tissues.
© 2012 Optical Society of America
OCIS Codes
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(350.5030) Other areas of optics : Phase
(170.6935) Medical optics and biotechnology : Tissue characterization
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: August 23, 2012
Revised Manuscript: October 16, 2012
Manuscript Accepted: November 10, 2012
Published: December 12, 2012
Virtual Issues
Vol. 8, Iss. 1 Virtual Journal for Biomedical Optics
Citation
Shang Wang, Jiasong Li, Ravi Kiran Manapuram, Floredes M. Menodiado, Davis R. Ingram, Michael D. Twa, Alexander J. Lazar, Dina C. Lev, Raphael E. Pollock, and Kirill V. Larin, "Noncontact measurement of elasticity for the detection of soft-tissue tumors using phase-sensitive optical coherence tomography combined with a focused air-puff system," Opt. Lett. 37, 5184-5186 (2012)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-37-24-5184
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