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Optics Letters

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  • Editor: Alan E. Willner
  • Vol. 37, Iss. 4 — Feb. 15, 2012
  • pp: 659–661

Double-illumination photoacoustic microscopy

Junjie Yao, Konstantin I. Maslov, Ernest R. Puckett, Kathryn J. Rowland, Brad W. Warner, and Lihong V. Wang  »View Author Affiliations


Optics Letters, Vol. 37, Issue 4, pp. 659-661 (2012)
http://dx.doi.org/10.1364/OL.37.000659


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Abstract

Recent developments of optical-resolution photoacoustic microscopy (OR-PAM) have improved its spatial resolution and imaging speed. However, the penetration depth of OR-PAM is still limited to 1mm in tissue, owing to the strong tissue scattering. Here, we have developed double-illumination PAM (DI-PAM), which illuminates the sample from both top and bottom sides simultaneously. Through phantom and in vivo experiments, we have demonstrated for thin targets that DI-PAM has a penetration depth of 2mm in tissue at 532 nm and a focal zone of 260 μm, both significant improvements over traditional reflection or transmission-mode OR-PAM.

© 2012 Optical Society of America

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(180.0180) Microscopy : Microscopy
(150.2945) Machine vision : Illumination design

ToC Category:
Microscopy

History
Original Manuscript: November 15, 2011
Manuscript Accepted: January 7, 2012
Published: February 13, 2012

Virtual Issues
Vol. 7, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Junjie Yao, Konstantin I. Maslov, Ernest R. Puckett, Kathryn J. Rowland, Brad W. Warner, and Lihong V. Wang, "Double-illumination photoacoustic microscopy," Opt. Lett. 37, 659-661 (2012)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-37-4-659


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