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Probing multifractality in tissue refractive index: prospects for precancer detection |
Optics Letters, Vol. 38, Issue 2, pp. 211-213 (2013)
http://dx.doi.org/10.1364/OL.38.000211
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Abstract
Multiresolution analysis on the spatial refractive index inhomogeneities in the epithelium and connective tissue regions of a human cervix reveals a clear signature of multifractality. Importantly, the derived multifractal parameters, namely, the generalized Hurst exponent and the width of the singularity spectrum, derived via multifractal detrended fluctuation analysis, shows interesting differences between tissues having different grades of precancers. The refractive-index fluctuations are found to be more anticorrelated, and the strength of multifractality is observed to be considerably stronger in the higher grades of precancers. These observations on the multifractal nature of tissue refractive-index variations may prove to be valuable for developing light-scattering approaches for noninvasive diagnosis of precancer and early-stage cancer.
© 2013 Optical Society of America
OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(290.0290) Scattering : Scattering
(170.6935) Medical optics and biotechnology : Tissue characterization
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: October 8, 2012
Revised Manuscript: December 11, 2012
Manuscript Accepted: December 11, 2012
Published: January 14, 2013
Virtual Issues
Vol. 8, Iss. 2 Virtual Journal for Biomedical Optics
Citation
Nandan Das, Subhasri Chatterjee, Jalpa Soni, Jaidip Jagtap, Asima Pradhan, Tapas K. Sengupta, Prasanta K. Panigrahi, I. Alex Vitkin, and Nirmalya Ghosh, "Probing multifractality in tissue refractive index: prospects for precancer detection," Opt. Lett. 38, 211-213 (2013)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-38-2-211
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