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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 38, Iss. 2 — Jan. 15, 2013
  • pp: 85–87

In vivo measurement of the average refractive index of the human crystalline lens using optical coherence tomography

Carolina de Freitas, Marco Ruggeri, Fabrice Manns, Arthur Ho, and Jean-Marie Parel  »View Author Affiliations

Optics Letters, Vol. 38, Issue 2, pp. 85-87 (2013)

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We present a method for measuring the average group refractive index of the human crystalline lens in vivo using an optical coherence tomography (OCT) system which, allows full-length biometry of the eye. A series of OCT images of the eye including the anterior segment and retina were recorded during accommodation. Optical lengths of the anterior chamber, lens, and vitreous were measured dynamically along the central axis on the OCT images. The group refractive index of the crystalline lens along the central axis was determined using linear regression analysis of the intraocular optical length measurements. Measurements were acquired on three subjects of age 21, 24, and 35 years. The average group refractive index for the three subjects was, respectively, n=1.41, 1.43, and 1.39 at 835 nm.

© 2013 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(330.5370) Vision, color, and visual optics : Physiological optics

ToC Category:
Imaging Systems

Original Manuscript: September 3, 2012
Revised Manuscript: November 21, 2012
Manuscript Accepted: December 5, 2012
Published: January 4, 2013

Virtual Issues
Vol. 8, Iss. 2 Virtual Journal for Biomedical Optics

Carolina de Freitas, Marco Ruggeri, Fabrice Manns, Arthur Ho, and Jean-Marie Parel, "In vivo measurement of the average refractive index of the human crystalline lens using optical coherence tomography," Opt. Lett. 38, 85-87 (2013)

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  1. Y. A. Chen, N. Himschall, and O. Findl, J. Cataract Refract. Surg. 37, 513 (2011). [CrossRef]
  2. T. Rabsiller, C. Jepsen, G. Auffarth, and M. Holzer, J. Cataract Refract. Surg. 36, 230 (2010). [CrossRef]
  3. C. Hitzenberger, Invest. Opthalmol. Vis. Sci. 32, 616 (1991).
  4. D. Atchison and G. Smith, J. Opt. Soc. Am. 22, 29 (2005). [CrossRef]
  5. W. Drexler, C. K. Hitzenberger, A. Baumgartner, O. Findl, H. Sattmann, and A. Fercher, Exp. Eye Res. 66, 25 (1998). [CrossRef]
  6. S. Uhlhorn, D. Borja, F. Manns, and J. M. Parel, Vis. Res. 48, 2732 (2008). [CrossRef]
  7. R. Augusteyn, A. Rosen, D. Borja, N. M. Ziebarth, and J. M. Parel, Mol. Vision 12, 740 (2006).
  8. G. L. Van der Heijde and J. Weber, Optom. Vis. Sci. 66, 830 (1989). [CrossRef]
  9. M. Ruggeri, S. Uhlhorn, C. de Freitas, A. Ho, F. Manns, and J. M. Parel, Biomed. Opt. Express 3, 1506 (2012). [CrossRef]
  10. E. Mallen, P. Kashyap, and K. Hampson, Invest. Ophthalmol. Vis. Sci. 47, 1251 (2006). [CrossRef]
  11. E. Woodman, S. Read, and M. Collins, Vis. Res. 72, 34 (2012). [CrossRef]
  12. W. Drexler, O. Findl, L. Schmetterer, C. K. Hitzenberger, and A. F. Fercher, Invest. Ophthalmol. Vis. Sci. 39, 2140 (1998).
  13. H. Uozato, K. Shimizu, R. Minei, and H. Suzuki, “Effect of accommodation on axial length measurment in optical coherence biometry,” presented at the annual meeting of the Association of Research in Vision and Ophthalmology, Ft. Lauderdale, Florida, May 2003.
  14. S. Kasthurirangan, E. Markwell, D. Atchison, and J. Pope, Invest. Ophthaimol. Visual Sci. 49, 2531 (2008). [CrossRef]
  15. D. Borja, D. Siedlecki, A. de Castro, S. Uhlhorn, S. Ortiz, E. Arrieta, J. M. Parel, S. Marcos, and F. Manns, Biomed. Opt. Express 1, 1331 (2010). [CrossRef]

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