We demonstrate a dual-wavelength band optical frequency domain imaging (OFDI) system that provides high-resolution spectroscopic imaging with metallic nanoparticles as exogenous contrast agents. The local increase of the OFDI signal by elastic scattering from two different custom-fabricated nonspherical nanoparticles resonant at each wavelength band of the system was successfully detected, and we were able to distinguish and visualize the location of each of the nanoparticles in a scattering sample and in biological tissue.
© 2014 Optical Society of America
Original Manuscript: March 26, 2014
Manuscript Accepted: April 11, 2014
Published: May 15, 2014
Vol. 9, Iss. 7 Virtual Journal for Biomedical Optics
Tae Shik Kim, Sun-Joo Jang, Nuri Oh, Yongjoo Kim, Taejin Park, Jiho Park, and Wang-Yuhl Oh, "Dual-wavelength band spectroscopic optical frequency domain imaging using plasmon-resonant scattering in metallic nanoparticles," Opt. Lett. 39, 3082-3085 (2014)