OSA's Digital Library

Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 14 — Jul. 15, 2014
  • pp: 4061–4064

Real-time optoacoustic tomography of indocyanine green perfusion and oxygenation parameters in human finger vasculature

Christian Lutzweiler, Reinhard Meier, Ernst Rummeny, Vasilis Ntziachristos, and Daniel Razansky  »View Author Affiliations


Optics Letters, Vol. 39, Issue 14, pp. 4061-4064 (2014)
http://dx.doi.org/10.1364/OL.39.004061


View Full Text Article

Enhanced HTML    Acrobat PDF (340 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We interrogated whether optoacoustic tomography could be employed to study blood functional parameters and biodistribution of injected fluorescent agents in humans. Using a multichannel scanner at a frame rate of 10 images per second, we obtained cross-sectional images of the human finger in real time, before and after the administration of indocyanine green. We demonstrated that multispectral optoacoustic tomography can sense fast flow kinetics and resolve spatiotemporal characteristics of a common fluorochrome in human vasculature at clinically relevant concentrations. We further register ICG images with oxygen saturation maps and anatomical views of the proximal interphalangeal joint of a healthy volunteer.

© 2014 Optical Society of America

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.5380) Medical optics and biotechnology : Physiology
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(110.6955) Imaging systems : Tomographic imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 11, 2014
Revised Manuscript: May 19, 2014
Manuscript Accepted: June 3, 2014
Published: July 2, 2014

Virtual Issues
Vol. 9, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Christian Lutzweiler, Reinhard Meier, Ernst Rummeny, Vasilis Ntziachristos, and Daniel Razansky, "Real-time optoacoustic tomography of indocyanine green perfusion and oxygenation parameters in human finger vasculature," Opt. Lett. 39, 4061-4064 (2014)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-39-14-4061


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. S. E. Burk, A. P. Da Mata, M. E. Snyder, R. H. Rosa, and R. E. Foster, Ophthalmology 107, 2010 (2000). [CrossRef]
  2. G. R. Cherrick, S. W. Stein, C. M. Leevy, and C. S. Davidson, J. Clin. Invest. 39, 592 (1960). [CrossRef]
  3. T. Iijima, T. Aoyagi, Y. Iwao, J. Masuda, M. Fuse, N. Kobayashi, and H. Sankawa, J. Clin Monit. 13, 81 (1997). [CrossRef]
  4. V. Ntziachristos, A. G. Yodh, M. Schnall, and B. Chance, Proc. Natl. Acad. Sci. USA 97, 2767 (2000).
  5. R. Meier, K. Thürmel, P. Moog, P. B. Noël, C. Ahari, M. Sievert, F. Dorn, S. Waldt, C. Schaeffeler, and D. Golovko, Arthritis Rheum. 64, 2489 (2012). [CrossRef]
  6. V. Ntziachristos, Nat. Methods 7, 603 (2010). [CrossRef]
  7. P. Beard, Interface Focus 1, 602 (2011). [CrossRef]
  8. D. Razansky, IEEE J. Sel. Topics Quantum Electron. 18, 1234 (2012).
  9. G. Ku and L. H. V. Wang, Opt. Lett. 30, 507 (2005). [CrossRef]
  10. L. Vionnet, J. Gateau, M. Schwarz, A. Buehler, V. Ermolayev, and V. Ntziachristos, IEEE Trans. Med. Imaging 33, 535 (2014). [CrossRef]
  11. X. L. Deán-Ben and D. Razansky, Photoacoustics 1, 68 (2013). [CrossRef]
  12. K. Jansen, M. Wu, A. F. W. van der Steen, and G. van Soest, Photoacoustics 2, 12 (2014). [CrossRef]
  13. J.-M. Yang, K. Maslov, H.-C. Yang, Q. Zhou, K. K. Shung, and L. V. Wang, Opt. Lett. 34, 1591 (2009). [CrossRef]
  14. M. Heijblom, D. Piras, W. Xia, J. van Hespen, J. Klaase, F. van den Engh, T. van Leeuwen, W. Steenbergen, and S. Manohar, Opt. Express 20, 11582 (2012). [CrossRef]
  15. A. Dima and V. Ntziachristos, Opt. Express 20, 25044 (2012). [CrossRef]
  16. G. Xu, J. R. Rajian, G. Girish, M. J. Kaplan, J. B. Fowlkes, P. L. Carson, and X. Wang, J. Biomed. Opt. 18, 010502 (2013). [CrossRef]
  17. Y. Sun, E. S. Sobel, and H. Jiang, Med. Phys. 38, 4009 (2011). [CrossRef]
  18. : For Safe Use of Lasers. Published by the Laser Institute of America.
  19. J. A. Viator, B. Choi, M. Ambrose, J. Spanier, and J. S. Nelson, Appl. Opt. 42, 3215 (2003). [CrossRef]
  20. A. Rosenthal, D. Razansky, and V. Ntziachristos, IEEE Trans. Med. Imaging 29, 1275 (2010). [CrossRef]
  21. M. Landsman, G. Kwant, G. Mook, and W. Zijlstra, J. Appl. Physiol. 40, 575 (1976).
  22. J.-M. Morel and G. Yu, SIAM J. Imaging Sci. 2, 438 (2009). [CrossRef]
  23. R. Meier, K. Thuermel, P. B. Noël, P. Moog, M. Sievert, C. Ahari, R. A. Nasirudin, D. Golovko, B. Haller, C. Ganter, M. Wildgruber, C. Schaeffeler, S. Waldt, and E. J. Rummeny, Radiology 270, 176 (2014). [CrossRef]
  24. B. M. Leslie, L. K. Ruby, S. J. Madell, and F. Wittenstein, J. Hand Surg. 12, 740 (1987).
  25. J. M. Kleinert, S. G. Fleming, C. S. Abel, and J. Firrell, J. Hand Surg. 14, 504 (1989).
  26. G. C. Sutton, J. Karnell, and G. Nylin, Am. Heart J. 39, 741 (1950). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1. Fig. 2. Fig. 3.
 

Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited