Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

In vivo OCT microangiography of rodent iris

Not Accessible

Your library or personal account may give you access

Abstract

We report on the functional optical coherence tomography (OCT) imaging of iris tissue morphology and microcirculation in living small animals. Anterior segments of healthy mouse and rat eyes are imaged with high-speed spectral domain OCT (SD-OCT) utilizing ultrahigh sensitive optical microangiography (UHS-OMAG) imaging protocol. 3D iris microvasculature is produced by the use of an algorithm that calculates absolute differences between the amplitudes of the OCT interframes. We demonstrate that the UHS-OMAG is capable of delineating iris microvascular beds in the mouse and rat with capillary-level resolution. Furthermore, the fast imaging speed enables dynamic imaging of iris micro-vascular response during drug-induced pupil dilation. We believe that this OCT angiographic approach has a great potential for in situ and in vivo monitoring of the microcirculation within iris tissue beds in rodent disease models that have microvascular involvement.

© 2014 Optical Society of America

Full Article  |  PDF Article
More Like This
In vivo imaging of the rodent eye with swept source/Fourier domain OCT

Jonathan J. Liu, Ireneusz Grulkowski, Martin F. Kraus, Benjamin Potsaid, Chen D. Lu, Bernhard Baumann, Jay S. Duker, Joachim Hornegger, and James G. Fujimoto
Biomed. Opt. Express 4(2) 351-363 (2013)

Optical microangiography of retina and choroid and measurement of total retinal blood flow in mice

Zhongwei Zhi, Xin Yin, Suzan Dziennis, Tomasz Wietecha, Kelly L. Hudkins, Charles E. Alpers, and Ruikang K Wang
Biomed. Opt. Express 3(11) 2976-2986 (2012)

Supercontinuum light source enables in vivooptical microangiography of capillary vessels within tissue beds

Zhongwei Zhi, Jia Qin, Lin An, and Ruikang K. Wang
Opt. Lett. 36(16) 3169-3171 (2011)

Supplementary Material (1)

Media 1: AVI (2921 KB)     

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (5)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved